HS-1793 NEW
| Price | $43 | $73 | $118 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: HS-1793 | CAS No.: 927885-00-5 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | HS-1793 |
| 描述 | HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model |
| 體外活性 | HS-1793 was found to inhibit hypoxia (1.0% oxygen)-induced HIF-1α expression at the protein level, and its inhibitory effect was more potent than that of resveratrol in MCF-7 and MDA-MB-231 breast cancer cells.?Furthermore, HS-1793 reduced the secretion and mRNA expression of vascular endothelial growth factor (VEGF), a key mediator of HIF-1-driven angiogenesis, without affecting cell viability. |
| 體內(nèi)活性 | HS-1793 significantly suppressed the growth of breast cancer tumor xenografts, without any apparent toxicity.?Additionally, decreases in Ki-67, a proliferation index marker, and CD31, a biomarker of microvessel density, were observed in the tumor tissue.?Expression of HIF-1 and VEGF was also downregulated in xenograft tumors treated with HS-1793.?These in vivo results reinforce the improved anticancer activity of HS-1793 when compared with that of resveratrol.?Overall, the present study suggests that the synthetic resveratrol analogue HS-1793 is a potent antitumor agent that inhibits tumor growth via the regulation of HIF-1, and demonstrates significant therapeutic potential for solid cancers. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 22.5 mg/mL (89.19 mM) |
| 關(guān)鍵字 | HIF-1α | Inhibitor | MCF-7 | breast cancer | inhibit | ERK | HS1793 | HCT116 | resveratrol | VEGF | Apoptosis | Akt | HS-1793 | colon cancer | HS 1793 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | HIF-1化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $185.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-14 | |
| $99.00/1EA |
Amikon Limited
|
2018-05-25 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY