HS-1371 NEW
| Price | $30 | $58 | $101 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: HS-1371 | CAS No.: 2158197-70-5 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | HS-1371 |
| 描述 | HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. |
| 體外活性 | HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, inhibiting TNF-induced necroptosis without affecting TNF-induced apoptosis. This indicates a specific inhibitory effect on RIP3-mediated necroptosis through the suppression of RIP3 kinase activity. HS-1371 may serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 16.67 mg/mL (43.36 mM) |
| 關(guān)鍵字 | Inhibitor | Receptor-interacting protein kinases | HS1371 | RIPK | HS-1371 | inhibit | RIP kinase | HS 1371 |
| 相關(guān)產(chǎn)品 | PK68 | Necrostatin-1 | RIPK2-IN-5 | Oditrasertib | LY-364947 | Necroptosis-IN-1 | ICCB-19 hydrochloride | RIPK1-IN-9 | Necrostatin-34 | RIPA-56 | GSK2983559 free acid | Zharp2-1 |
| 相關(guān)庫(kù) | NF-κB 通路分子庫(kù) | 經(jīng)典已知活性庫(kù) | HIF-1化合物庫(kù) | 激酶抑制劑庫(kù) | 細(xì)胞焦亡化合物庫(kù) | 抑制劑庫(kù) | 抗前列腺癌化合物庫(kù) | PPI抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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