Product Details
| Product Name:
GW6471 |
CAS No.:
880635-03-0 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | GW6471 |
| 描述 | GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR. |
| 體外活性 | METHODS: RCC cells Caki-1 (VHL wild type) and 786-O (VHL mutant) were treated with GW6471 (12.5-100 μM) for 72 h. Cell viability was measured using MTT assay. |
| 體內(nèi)活性 | METHODS: To assay in vivo antitumor activity, GW6471 (20 mg/kg) was injected intraperitoneally every two days for four weeks into Nu/Nu mice bearing the RCC tumor Caki-1.
RESULTS: In vivo treatment of xenograft mouse model with PPARα antagonist GW6471 attenuated RCC growth. [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 16.67 mg/mL (26.9 mM), Sonication is recommended.
10% DMSO+90% Saline : 0.25 mg/mL (0.4 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
|
| 關(guān)鍵字 | Peroxisome proliferator-activated receptors | Inhibitor | inhibit | GW-6471 | PPAR | GW6471 |
| 相關(guān)產(chǎn)品 | PHYTOL | (S)-(+)-Ibuprofen | BADGE | Cinnamyl alcohol | Daidzein | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin |
| 相關(guān)庫 | 核受體化合物庫 | 經(jīng)典已知活性庫 | 抗糖尿病庫 | 抑制劑庫 | NO PAINS 化合物庫 | 線粒體靶向庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States