Antipsychotic agent 54 NEW
| Price | $82 | $197 | $328 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Antipsychotic agent 54 | CAS No.: 666859-49-0 |
| Purity: 97.39% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Antipsychotic agent 54 |
| 描述 | Antipsychotic agent 54 is a benzoylpiperidine compound that can be used in the study of central nervous system diseases such as psychosis and cognitive impairment. |
| 體外活性 | Treatment of SMMC-7721 cells with Telomerase-IN-1 (20, 40, and 80 nM) for 48 hours results in significant accumulation of green fluorescence, demonstrating a decrease in mitochondrial membrane potential (MMP). At 40 nM, Telomerase-IN-1 notably enhances the expression of cytochrome c (cyt-c) and Bax, while reducing Bcl-2 levels. Our in vitro findings illustrate that Telomerase-IN-1 exhibits robust inhibitory effects on telomerase, displaying significant antiproliferative activity against SMMC-7721 cells without apparent toxicity towards human normal hepatocyte cells. Telomerase-IN-1 treatment reduces cancer cell growth in both dose- and time-dependent manners, with minimal impact on the viability of L-02 cells at 10 μM. A noteworthy increase in apoptosis is observed following 48 hours of treatment with Telomerase-IN-1 at concentrations of 20, 40, and 80 nM. |
| 體內(nèi)活性 | Our in vivo studies demonstrate a significant inhibition of tumor growth in xenograft tumor models by Telomerase-IN-1. Our findings indicate that the compound triggers endoplasmic reticulum stress (ERS) via an excessive ER response (EOR), leading to the activation of hTERT expression. Subsequently, this ERS induction, intricately linked to oxidative stress and mitochondrial dysfunction, initiates apoptotic cell death and modulates downstream signaling molecules, including CHOP (CAAT/enhancer-binding protein homologous protein), as well as the mitochondrion pathway of apoptosis. As a result, cell proliferation is effectively suppressed.[1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 90.0 mg/mL (232.9 mM), Sonication is recommended. |
| 關(guān)鍵字 | Telomerase IN 1 | Telomerase-IN-1 | TelomeraseIN1 |
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| 相關(guān)庫 | 細胞凋亡化合物庫 | DNA 損傷和修復(fù)分子庫 | 經(jīng)典已知活性庫 | 內(nèi)質(zhì)網(wǎng)應(yīng)激化合物庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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