Glembatumumab vedotin NEW
| Price | $718 | $1520 | $1980 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Glembatumumab vedotin | CAS No.: 1182215-65-1 |
| Purity: > 95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Glembatumumab vedotin |
| Description | Glembatumumab vedotin (CDX-011) is an antibody-drug conjugate with potent anticancer effects, utilized in the study of triple negative breast cancer (TNBC). |
| In vitro | Glembatumumab vedotin binds to GPNMB on tumor cells, and the complex is internalized. Within the lysosomal compartment, the protein linker containing monomethyl auristatin E (MMAE) is enzymatically cleaved, releasing MMAE, which inhibits microtubules, leading to cell cycle arrest and subsequent tumor cell death[1]. Glembatumumab vedotin exhibits cytotoxic activity against osteosarcoma cells at concentrations ranging from 1 to 125 μg/mL over a 96-hour period[2]. |
| In vivo | In human SK-MEL-2 and SK-MEL-5 melanoma xenograft models, Glembatumumab vedotin (CR011-vcMMAE) demonstrates both short-term antitumor effects (inhibiting tumor growth) and long-term effects (complete regression) when administered via intravenous injection at doses ranging from 1.25 to 80 mg/kg, every 4 days, for a duration of 16 days[3]. |
| Storage | keep away from direct sunlight,store at low temperature | Shipping with blue ice. |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | 4-Isopropoxybenzoic acid | Oxfendazole | Docetaxel | Thiabendazole | Methylene Blue | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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