Brentuximab vedotin NEW
| Price | $413 | $979 | $1960 |
| Package | 1mg | 5mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Brentuximab vedotin | CAS No.: 914088-09-8 |
| Purity: 97.73% (SEC-HPLC) | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Brentuximab vedotin |
| Description | Brentuximab vedotin (SGN-35) is a CD30-targeting antibody-active molecule conjugate (ADC) that combines a CD30 monoclonal antibody with the microtubule disrupting agent monomethylauristatin E for the study of lymphoma. |
| In vitro | METHODS: Three cancer cell lines derived from hematological malignancies (HH, DND-41, and MOLT-4 cells) were treated with Brentuximab vedotin (0.0068, 0.020, 0.068, 0.20, 0.68, 2.0, 6.8, 20, 68 nM, 72 hours) and cell viability was measured using the CellTiter-Glo luminescence assay. RESULTS: Brentuximab vedotin reduced the viability of HH cells in a dose-dependent manner with an IC50 value of 0.058 nM, but did not reduce the viability of DND-41 and MOLT-4 cells. [3] |
| In vivo | METHODS: Brentuximab vedotin (0.1 mg/kg, once a week, intravenously), chidamide (15 mg/kg, once a day, orally), or BV combined with chidamide were used to treat severe combined immunodeficient mice bearing tumor xenografts of HH cells mixed with BD Matrigel to study tumor growth in vivo. RESULTS: The combination of brentuximab vedotin and chidamide effectively inhibited tumor growth. [3] |
| Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. |
| Inhibitors Related | Disitamab vedotin | Trastuzumab emtansine | Cantuzumab ravtansine | Datopotamab deruxtecan | Glembatumumab vedotin | Labetuzumab govitecan | Cantuzumab mertansine | Moxetumomab pasudotox | Sacituzumab govitecan | Zilovertamab vedotin | Loncastuximab tesirine | Trastuzumab deruxtecan |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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