Finerenone NEW
| Price | $31 | $74 | $116 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Finerenone | CAS No.: 1050477-31-0 |
| Purity: 99.72% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Finerenone |
| 描述 | Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes. |
| 體外活性 | METHODS: Human smooth muscle cells SMC and human endothelial cells EC were treated with aldosterone (1-50 nM) and Finerenone (1-10 nM) for 24 h. Cell proliferation was detected by BrdU incorporation assay. RESULTS: After stimulation with aldosterone, the proliferation rate of SMC increased significantly. Although treatment with 1 nM concentration of Finerenone showed a clear tendency to decrease the SMC proliferation rate, 10 nM Finerenone adequately and significantly blocked aldosterone-induced SMC proliferation. However, aldosterone did not affect EC proliferation in vitro, nor did Finerenone. [1] METHODS: HK-GFP-hMR cells were treated with aldosterone (10 nM) and Finerenone (1 μM) for 3 h. The gene expression levels were measured by RT-qPCR. RESULTS: Finerenone was effective in antagonizing some aldosterone-induced genes. [2] |
| 體內(nèi)活性 | METHODS: To investigate the effects on vascular remodeling after acute vascular injury, Finerenone (1-10 mg/kg) was administered orally once daily for 21 days to wire-induced femoral artery dilated C57BL/6 mice. RESULTS: Finerenone treatment inhibited intimal and intermediate cell proliferation after wire-induced injury in mouse femoral arteries at 10 days post-injury and attenuated the formation of neoplastic intimal injury at 21 days post-injury. [1] |
| 存儲(chǔ)條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/ml (158.55 mM) H2O : Insoluble |
| 關(guān)鍵字 | inhibit | cardiorenal | systolic | disease | pressure | diabetes | chronic | type | Finerenone | Inhibitor | kidney | Mineralocorticoid Receptor | oral | nonsteroidal | blood |
| 相關(guān)產(chǎn)品 | Nimodipine | Hydrocortisone | Mifepristone | Prednisolone acetate | Beclometasone | Cortisone | Dexamethasone acetate | Prednisolone | Dexamethasone Phosphate disodium | Prednisone acetate | Desonide | Corticosterone |
| 相關(guān)庫(kù) | 高選擇性抑制劑庫(kù) | 經(jīng)典已知活性庫(kù) | EMA 上市藥物庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | FDA 上市藥物庫(kù) | 抗癌上市藥物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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