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Postion:Product Catalog >ONC212
ONC212
  • ONC212

ONC212 NEW

Price $44 $98 $162
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: ONC212 CAS No.: 1807861-48-8
Purity: ≥95% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱ONC212
描述ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.
體外活性In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility[1].
體內(nèi)活性ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 50 mg/mL (113.52 mM)
關(guān)鍵字Inhibitor | inhibit | Apoptosis | ONC212 | ONC 212 | ONC-212
相關(guān)產(chǎn)品Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride
相關(guān)庫細(xì)胞凋亡化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 血液病分子庫 | 已知活性化合物庫 | 臨床前化合物庫 | GPCR靶點(diǎn)分子庫 | 抗癌化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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