(E/Z)-BCI NEW
| Price | $73 | $157 | $297 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: (E/Z)-BCI | CAS No.: 15982-84-0 |
| Purity: 98.55% | Supply Ability: 10g |
| Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | (E/Z)-BCI |
| 描述 | (E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
| 體外活性 | (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly reduces cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. Additionally, (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages, while also inhibiting cell proliferation, migration, and invasion in a receptor-independent manner, enhancing Cisplatin (CDDP) cytotoxicity, and promoting apoptosis in GC cells. Moreover, (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) significantly suppresses IL-1β, TNF-α, and IL-6 mRNA expression in LPS-activated macrophages, decreases ROS production, and activates the Nrf2 pathway. |
| 體內(nèi)活性 | (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 20 mg/mL (60.00 mM）, Sonication is recommended. DMSO : 50 mg/mL (157.52 mM), Sonication is recommended. |
| 關(guān)鍵字 | ROS | Phosphatase | NSC-150117 | NSC150117 | Nrf2 | NF-κB | LPS | Inhibitor | inhibit | gastric cancer | ERK | DUSP6 | death | Apoptosis | anti-inflammatory | (E/Z)-BCI | (E/Z)BCI | (E/Z) BCI |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Tributyrin | Stearic acid | Salicylic acid | Oleic acid |
| 相關(guān)庫(kù) | 細(xì)胞凋亡化合物庫(kù) | 糖代謝化合物庫(kù) | NF-κB 通路分子庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 代謝化合物庫(kù) | 免疫/炎癥分子化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 磷酸酶抑制劑化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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