(E/Z)-BCI NEW
| Price | $73 | $157 | $297 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: (E/Z)-BCI | CAS No.: 15982-84-0 |
| Purity: 98.55% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | (E/Z)-BCI |
| Description | (E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
| In vitro | (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly reduces cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. Additionally, (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages, while also inhibiting cell proliferation, migration, and invasion in a receptor-independent manner, enhancing Cisplatin (CDDP) cytotoxicity, and promoting apoptosis in GC cells. Moreover, (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) significantly suppresses IL-1β, TNF-α, and IL-6 mRNA expression in LPS-activated macrophages, decreases ROS production, and activates the Nrf2 pathway. |
| In vivo | (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 20 mg/mL (60.00 mM）, Sonication is recommended. DMSO : 50 mg/mL (157.52 mM), Sonication is recommended. |
| Keywords | ROS | Phosphatase | NSC-150117 | NSC150117 | Nrf2 | NF-κB | LPS | Inhibitor | inhibit | gastric cancer | ERK | DUSP6 | death | Apoptosis | anti-inflammatory | (E/Z)-BCI | (E/Z)BCI | (E/Z) BCI |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Tributyrin | Stearic acid | Salicylic acid | Oleic acid |
| Related Compound Libraries | Apoptosis Compound Library | Glycometabolism Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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