BMS 182874 NEW
| Price | $68 | $163 | $263 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: BMS 182874 | CAS No.: 153042-42-3 |
| Purity: 98.38% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱(chēng) | BMS 182874 |
| 描述 | BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease. |
| 體外活性 | BMS-182874 (dimethyla minonalogue 11) is an effective functional antagonist of ETA-induced intracellular Ca2+ increase, with an IC50 value of 0.150 μM in vs-A10 cells. Ki value is 0.055 μM. The KB value in the rabbit carotid artery ring is 0.520 μM/[1] |
| 體內(nèi)活性 | BMS 182874 (100 μM/kg; Single oral) administration causes a slow decrease of 25% in arterial blood pressure from the control level. After 12 and 24 hours of administration, arterial blood pressure remained 12% lower than the control level.[1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (159.23 mM) |
| 關(guān)鍵字 | BMS 182874 |
| 相關(guān)產(chǎn)品 | Macitentan | Bosentan | BMS 182874 hydrochloride | Sitaxsentan sodium | Edonentan | Sulfisoxazole | Ambrisentan | Sparsentan | Aprocitentan | Sitaxsentan | Nebentan potassium | Clazosentan |
| 相關(guān)庫(kù) | 疼痛相關(guān)化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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