BMS 182874 hydrochloride NEW
| Price | $74 | $98 | $151 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: BMS 182874 hydrochloride | CAS No.: 1215703-04-0 |
| Purity: 97.01% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | BMS 182874 hydrochloride |
| 描述 | BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. |
| 體外活性 | BMS-l 82874 inhibited ET-l -stimulated inositol phosphate accumulation (KB 75 nM) and calcium mobilization (Ki = 140 nM) without suppressing the maximal responses in VSM-A10 cells. BMS-182874 competitively inhibited the binding of [125I]ET-1 to ETA receptors in rat vascular smooth muscle A10 (VSM-A10) cell membranes (Ki = 61 nM) and in CHO cells stably expressing the human ETA receptor (Ki = 48 nM), but was a weak inhibitor at ETB receptors (Ki > 50 μM) and non-ET receptors. |
| 體內(nèi)活性 | BMS-182874 blunted the pressor response to exogenous ET-l when administered either orally (ED50 = 30 μmol/kg) or intravenously (ED50 = 24 μmol/kg) to conscious, normotensive rats. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (130.93 mM) |
| 關鍵字 | BMS-182874 Hydrochloride | BMS182874 Hydrochloride | BMS 182874 hydrochloride | BMS 182874 Hydrochloride |
| 相關產(chǎn)品 | Macitentan | BMS 182874 | Bosentan | Sitaxsentan sodium | Edonentan | Sulfisoxazole | Ambrisentan | Sparsentan | Aprocitentan | Sitaxsentan | Nebentan potassium | Clazosentan |
| 相關庫 | 表型篩選靶點鑒定庫 | 經(jīng)典已知活性庫 | 疼痛相關化合物庫 | 膜蛋白靶向化合物庫 | ReFRAME 相關化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 臨床前化合物庫 | GPCR靶點分子庫 | 抗癌化合物庫 | 抗高血壓化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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