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Batabulin NEW

Price	$43	$122	$178
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-01

Product Details

Product Name: Batabulin	CAS No.: 195533-53-0
Purity: 99.85%	Supply Ability: 10g
Release date: 2024/11/01

Product Introduction

Bioactivity

名稱	Batabulin
描述	Batabulin (T138067) is an antitumor compound that binds covalently and selectively to a subset of the β-tubulin isotypes, disrupting microtubule polymerization. This disruption affects cell morphology, induces cell-cycle arrest, and ultimately leads to apoptotic cell death.
體外活性	In MCF7 cells, the treatment of Batabulin (T138067; 30-300 nM; 24 hours) shows approximately 25-30% tetraploid (4n) DNA content in cells and 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis. Batabulin binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape.
體內(nèi)活性	Batabulin (40 mg/kg; i.p.; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors.
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 100 mg/mL (269.35 mM), Sonication is recommended.
關(guān)鍵字	multidrug-resistant \| polymerization \| cytoskeleton \| covalent \| Apoptosis \| Cys-239 \| β-tubulin \| arrest \| Inhibitor \| Microtubule/Tubulin \| Antimitotic \| inhibit \| T 138067 \| Batabulin \| T-138067 \| cell-cycle \| antitumor
相關(guān)產(chǎn)品	Stavudine \| 5-Fluorouracil \| Kaempferol \| Myricetin \| Meclizine dihydrochloride \| Sodium 4-phenylbutyrate \| L-Ascorbic acid \| Metronidazole \| Sorafenib \| Tributyrin \| Salicylic acid \| Oleic acid
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.