Product Details
| Product Name:
Batabulin |
CAS No.:
195533-53-0 |
| Purity:
99.85% |
Supply Ability:
10g |
| Release date:
2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | Batabulin |
| 描述 | Batabulin (T138067) is an antitumor compound that binds covalently and selectively to a subset of the β-tubulin isotypes, disrupting microtubule polymerization. This disruption affects cell morphology, induces cell-cycle arrest, and ultimately leads to apoptotic cell death. |
| 體外活性 | In MCF7 cells, the treatment of Batabulin (T138067; 30-300 nM; 24 hours) shows approximately 25-30% tetraploid (4n) DNA content in cells and 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis. Batabulin binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape. |
| 體內(nèi)活性 | Batabulin (40 mg/kg; i.p.; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (269.35 mM), Sonication is recommended.
|
| 關(guān)鍵字 | multidrug-resistant | polymerization | cytoskeleton | covalent | Apoptosis | Cys-239 | β-tubulin | arrest | Inhibitor | Microtubule/Tubulin | Antimitotic | inhibit | T 138067 | Batabulin | T-138067 | cell-cycle | antitumor |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Kaempferol | Myricetin | Meclizine dihydrochloride | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid | Oleic acid |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 微管靶向化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:1393-63-1
$195.00 / 1mg
-
CAS:195533-98-3
$68.00 / 2mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$43.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-01 |
United States