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Postion:Product Catalog >API>Antiparasitic drugs>Antimalarial drugs>Artesunate
Artesunate
  • Artesunate
  • Artesunate
  • Artesunate

Artesunate NEW

Price Get Latest Price
Package 1kg 25kg
Min. Order: 1kg
Supply Ability: 500kg
Update Time: 2024-11-08
Related documents: COA

Product Details

Product Name: Artesunate CAS No.: 88495-63-0
EC-No.: 618-170-5 Min. Order: 1kg
Purity: 99% Supply Ability: 500kg
Release date: 2024/11/08

Specification


CharacteristicsWhite crystalline powder
Optical rotation+4.5°~+6.5°

IR

Consistent whith the reference spectrum.

HPLC:

The retention time of the

principle peak obtained with the test solution corresponds to the

peak obtained with the control solution.

Acidity3.5-4.5
Chloride0.02%

Dihydroartemisinin

0.5%

Welcome to contact us to get complete COA.


What is Artesunate?

Artesunate is a medication derived from artemisinin, a natural compound extracted from the sweet wormwood plant (Artemisia annua). It is used primarily for the treatment of severe malaria caused by Plasmodium falciparum, which is known for its resistance to other antimalarial drugs. Artesunate is known for its rapid action and high efficacy against malaria parasites.

Chemical Structure and Properties

  • Chemical Formula: C19H28O8

  • Molecular Weight: 384.42 g/mol

  • Appearance: White to off-white crystalline powder

  • Solubility: Soluble in water, ethanol, and DMSO (dimethyl sulfoxide)

Mechanism of Action

Artesunate works by generating reactive oxygen species (ROS) and carbon-centered free radicals upon activation. These reactive intermediates attack the proteins and membranes of the malaria parasite, leading to its rapid death. The exact mechanism involves the cleavage of endoperoxide bridges within the parasite's food vacuole, leading to lethal damage.

Applications of Artesunate

1. Malaria Treatment

Severe Malaria

  • Artesunate is the preferred treatment for severe malaria, especially in cases caused by P. falciparum. It is administered intravenously or intramuscularly for rapid action.

Uncomplicated Malaria

  • Artesunate is also used in combination therapies for treating uncomplicated malaria. It is often combined with other antimalarial drugs like mefloquine, amodiaquine, or sulfadoxine-pyrimethamine to enhance efficacy and reduce the risk of resistance.

2. Other Potential Applications

Cancer Research

  • Artesunate has shown potential anticancer properties in preclinical studies. Its ability to generate ROS and induce apoptosis (programmed cell death) makes it a candidate for further research in cancer therapy.

Autoimmune Diseases

  • Some studies are exploring artesunate's immunomodulatory effects, which could be beneficial in treating autoimmune diseases. However, more research is needed to confirm these applications.

Benefits of Artesunate

  • Rapid Action: Artesunate acts quickly to reduce the number of malaria parasites in the blood, making it highly effective in severe cases.

  • High Efficacy: It is highly effective against multi-drug resistant strains of P. falciparum.

  • Reduced Mortality: The use of artesunate in severe malaria has been shown to significantly reduce mortality rates compared to other treatments like quinine.

Side Effects

  • Common Side Effects: Nausea, vomiting, dizziness, and headache.

  • Serious Side Effects: Rare but may include hemolysis (destruction of red blood cells), severe allergic reactions, and liver enzyme elevation.



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Company Profile Introduction

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

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