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Postion:Product Catalog >API>Nervous system drugs>Antidepressants, Antimanics drugs>Agomelatine
Agomelatine
  • Agomelatine

Agomelatine NEW

Price $57 $76 $143
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Agomelatine CAS No.: 138112-76-2
Purity: 99.92% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameAgomelatine
DescriptionAgomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
In vitroAgomelatine enhances cell proliferation and neurogenesis in the ventral hippocampus (VH) of adult rats, a region associated with emotional disorders. It effectively reverses behavior alterations in transgenic mice observed in Porsolt forced swimming tests and elevated plus mazes. Agomelatine significantly accelerates the re-adjustment of circadian rhythms of temperature and activity after induced phase shifts. It increases the duration of positive social interactions in mice exposed to new environments. In the ventral dentate gyrus of rats, which is involved in emotional responses, Agomelatine promotes cell proliferation and neurogenesis, consistent with its anti-depressant and anti-anxiety properties. Across the entire dentate gyrus, Agomelatine boosts the survival of newly generated neurons. It enhances the ratio of mature to immature neurons and promotes dendritic sprouting in the granule cells of adult rats, indicating accelerated maturation. Furthermore, Agomelatine activates several cellular signaling pathways (extracellular signal-regulated kinases 1/2, protein kinase B, and glycogen synthase kinase 3 beta) known to be modulated by antidepressants and involved in proliferation/survival control.
In vivoIn mice subjected to chronic electroshock stress, Agomelatine fully normalized the survival of stress-affected cells in the hippocampus and partially reversed the reduction in glucocorticoid receptor expression.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 48 mg/mL (197.29 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 42 mg/mL (172.6 mM)
Keywords5-HT Receptor | disorder | S 20098 | depressive | antidepressant | Inhibitor | 5-hydroxytryptamine Receptor | MT1 | inhibit | Antagonist | S20098 | Agonist | 5-HT2C | Agomelatine | MT2 | Melatonin Receptor | Serotonin Receptor
Inhibitors RelatedAlverine citrate | Dapoxetine hydrochloride | Melatonin
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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