Agomelatine hydrochloride NEW
| Price | $31 | $51 | $92 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: Agomelatine hydrochloride | CAS No.: 1176316-99-6 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | Agomelatine hydrochloride |
| 描述 | Agomelatine hydrochloride (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki values of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, respectively [1]. Additionally, Agomelatine hydrochloride is a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native (porcine) and cloned human 5-HT2C receptors, respectively [2]. |
| 體外活性 | Agomelatine (S 20098) functions as a full agonist for the MT1 and MT2 receptors, exhibiting EC50 values of 1.6±0.4 and 0.10±0.04 nM, respectively, when expressed in CHO or HEK cell membranes. Additionally, Agomelatine interacts with h5-HT2B receptors, displaying a marked preference (6.6). However, it demonstrates low affinity for both native and cloned human 5-HT2A receptors, with values just below 5.0/5.3, and similarly low affinity for 5-HT1A receptors (below 5.0/5.2), while exhibiting negligible affinity for other 5-HT receptors. |
| 體內(nèi)活性 | Agomelatine (25, 50, or 75 mg/kg; i.p.) exhibits antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice, but does not affect oxidative stress parameters in Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models compared to controls[3]. |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | H2O : 0.1 mg/mL (insoluble) DMSO : 90 mg/mL (321.7 mM) |
| 關(guān)鍵字 | S-20098 Hydrochloride | Agomelatine Hydrochloride | S 20098 Hydrochloride | S20098 Hydrochloride |
| 相關(guān)產(chǎn)品 | 8-M-PDOT | Ramelteon | ACH-000143 | glycine | 4-P-PDOT | Tasimelteon | Piromelatine | S26131 | Luzindole |
| 相關(guān)庫 | FDA上市及藥典收錄分子庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 抗抑郁癥化合物庫 | 神經(jīng)信號(hào)分子庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $57.00/5mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $0.00/25kg |
VIP1Y
|
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
|
2024-05-17 | |
| $1.00/1kg |
VIP4Y
|
Dorne Chemical Technology co. LTD
|
2024-03-26 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY