Ademetionine 1,4-Butanedisulfonate (CAS: 1014692-62-6)

Chemical Information

• IUPAC Name: S-Adenosyl-L-methionine 1,4-butanedisulfonate

• Synonyms: SAMe butanedisulfonate, Ademetionine butanedisulfonate, SAMe tosylate disulfate

• Molecular Formula: C15H24N6O5S2·C4H10O6S2

• Molecular Weight: 534.61 g/mol

Structure and Properties

• Chemical Structure: This compound consists of S-adenosyl-L-methionine (SAMe) bound to 1,4-butanedisulfonic acid. SAMe is a naturally occurring compound formed from methionine and ATP.

• Appearance: White to off-white crystalline powder.

• Solubility: Soluble in water and aqueous solutions.

Biological Significance

• Role in Biochemistry: SAMe is involved in methyl group transfers, which are essential for various biochemical processes, including the methylation of DNA, proteins, and lipids.

• Therapeutic Uses: Used as a dietary supplement and in pharmaceuticals for its potential benefits in treating depression, liver diseases, and osteoarthritis. SAMe is known for its mood-enhancing and liver-protective properties.

Applications and Uses

• Medical and Dietary Supplement: Ademetionine 1,4-butanedisulfonate is used for its potential therapeutic effects on mood disorders, liver function, and joint health. It is taken as an oral supplement or administered via injection.

• Biochemical Research: Studied extensively for its role in methylation reactions and its involvement in the synthesis of various biomolecules.

Safety and Handling

When handling Ademetionine 1,4-butanedisulfonate, standard safety practices should be followed:

• Personal Protective Equipment (PPE): Use appropriate gloves, protective eyewear, and lab coats.

• Storage: Store in a cool, dry place, away from incompatible substances.

• Hazards: Refer to the Material Safety Data Sheet (MSDS) for detailed information on potential hazards, safe handling practices, and first aid measures.

Resources and References

Ademetionine 1,4-butanedisulfonate is significant in both clinical and research contexts due to its role in methylation reactions and therapeutic potential. For precise safety guidelines, always refer to the specific Material Safety Data Sheet (MSDS) provided by the manufacturer or supplier.