A 582941 HCl (848591-90-2(free base)) NEW
| Price | $80 | $181 | $272 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: A 582941 HCl (848591-90-2(free base)) | Purity: 99.83% |
| Supply Ability: 10g | Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | A 582941 HCl (848591-90-2(free base)) |
| 描述 | A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties |
| 體外活性 | A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 12 mg/mL (37.88 mM) |
| 關鍵字 | A 582941 HCl (848591-90-2(free base)) | A 582941 HCl (848591902(free base)) | A 582941 HCl (848591 90 2(free base)) |
| 相關產(chǎn)品 | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Olanzapine | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Amitriptyline hydrochloride | Choline chloride | Propoxur |
| 相關庫 | 神經(jīng)退行性疾病化合物庫 | 疼痛相關化合物庫 | 經(jīng)典已知活性庫 | 抗阿爾茨海默癥化合物庫 | 神經(jīng)信號分子庫 | 膜蛋白靶向化合物庫 | 神經(jīng)遞質(zhì)受體化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 離子通道庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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