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Postion:Product Catalog >API>Circulatory system drugs>Antihypertensive drugs>Valsartan
Valsartan
  • Valsartan

Valsartan

Price $20
Package 1KG
Min. Order: 10KG
Supply Ability: 10MT
Update Time: 2019-01-15

Product Details

Product Name: Valsartan CAS No.: 137862-53-4
Min. Order: 10KG Purity: 99%
Supply Ability: 10MT Release date: 2019/01/15
Usage : Blood pressure medicine Appearance: White to almost white powder

Description

 

Valsartan belong to non peptide, orally active angiotensin Ⅱ ( AT ) receptor antagonist. It is highly selective for Ⅰ type ( AT1 ) receptor, can be competitive antagonism to without any excitement. It can also be mediated by inhibition of AT1 receptor adrenal cells release aldehyde sterol, but for potassium caused by the release of valsartan no inhibition, it also suggests that valsartan for AT1 receptor selectivity.

 

The experiments of various types of hypertensive animal models showed that valsartan had a good hypotensive effect, which had no significant effect on cardiac systolic function and heart rate. Animals with normal blood pressure do not have a blood pressure lowering effect. The uptake was rapid and bioavailability was 23 %. The binding rate of plasma protein was 94% ~ 97%. About 70% of the excrement is excreted, and 30% of the renal excretion is in the original form. T1 over 2 beta is about 9 hours. It is not affected by the combination of food and food.

 

The blood pressure began to decline after 2 hours after taking a patient with high blood pressure, and the maximum blood pressure effect was reached between 4 and 6 hours. The hypotensive effect lasts for 24 hours. The maximal effect of blood pressure was decreased by 2 ~ 4 weeks after continuous use. It can be used in combination with hydrochlorothiazide, and the blood pressure can be enhanced.

 

Uses

 

Blood pressure medicine. Valsartan for angiotensin Ⅱ ( Ang Ⅱ) receptor antagonist, can selectively block Ang Ⅱ combined with AT1 receptor ( its specificity of AT1 receptor of antagonism effect about 20000 times greater than AT2 ), thus inhibiting vascular contraction and the release of aldosterone, antihypertensive effect.

 

Contraindications

 

The packaging for valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes mellitus. It also states the drug should not be used in people with kidney disease.

 

Valsartan falls in FDA pregnancy category D and includes a black box warning for fetal toxicity. Discontinuation of these agents is recommended immediately after detection of pregnancy and an alternative medication should be started. The US labeling makes no recommendation regarding continuation or discontinuation of valsartan for breast-feeding mothers. The Canadian labeling does not recommend use by nursing women.

 

Specification

 

Item Specification Result
Appearance White to almost white powder White powder
Identification Infrared absorption: The IR spectrum is consistent with that obtained with the reference Conforms
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. Conforms
Absorbance NMT 0.02% Conforms
Water NMT 2.0% 0.51%
Residue on ignition NMT 0.1% 0.07%
Heavy metals NMT 0.001% Complies
Related compounds ( HPLC ) Compound A NMT 1.0% 0.59%
Compound B NMT 0.2% 0.04%
Compound C NMT 0.1% 0.05%
Any other individual impurity NMT 0.1% ( excluding compound A ) 0.07%
Total impurities NMT 0.3% ( excluding compound A ) 0.16%
Residual solvents ( GC ) Ethyl acetate NMT 5000ppm 305ppm
Dichloromethane NMT 600ppm Undetected
Methanol NMT 3000ppm Undetected
N, N - Dimethylformamide NMT 880PPM Undetected
Assay ( HPLC ) 98.0%~102.0% 99.65%

 

Advantages:
 
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.


1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


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4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

Valsartan 137862-53-4 Pharmaceutical Raw Materials

Valsartan 137862-53-4 Pharmaceutical Intermediate

Valsartan 137862-53-4 Raw Chemical Product

Valsartan 137862-53-4 Supplier & manufactuer 

 

Company Profile Introduction

Hubei XinRunde Chemical Co., Ltd covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Products sell well all over the country and exported to Europe and the United States and Southeast Asia,and so on.

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