萘法唑酮鹽酸鹽
| 中文名稱 | 萘法唑酮鹽酸鹽 |
|---|---|
| 中文同義詞 | 萘法唑酮鹽酸鹽;鹽酸奈法唑酮;鹽酸萘法唑酮;鹽酸奈法唑酮 標準品;萘法唑酮鹽酸鹽 USP標準品;DUTONIN|||MJ-13754-1|||SERZONE|||BMY-13754-1|||BMY-13754|||萘法唑酮鹽酸鹽;1-(3-(4-(3-氯苯基)哌嗪-1-基)丙基)-3-乙基-4-(2-苯氧基乙基)-1H-1,2,4-三唑-5(4H)-酮鹽酸鹽;乙腈中奈法唑酮鹽酸鹽(以奈法唑酮計) |
| 英文名稱 | Nefazodone hydrochloride |
| 英文同義詞 | NEFAZODONE-D5 HCL;3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride;Nefazodone HCl;Nefazodone hydrochloride;NEFAZODONE;BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;Nefazodone Hydrochloride (200 mg) |
| CAS號 | 82752-99-6 |
| 分子式 | C25H33Cl2N5O2 |
| 分子量 | 506.47 |
| EINECS號 | |
| 相關(guān)類別 | 醫(yī)藥原料藥;哌嗪;SERZONE;Active Pharmaceutical Ingredients;Serotonin receptor;API;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 82752-99-6.mol |
| 結(jié)構(gòu)式 |  |
萘法唑酮鹽酸鹽 性質(zhì)
| 熔點 | 186-188°C |
|---|---|
| 儲存條件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMSO: 11 mg/mL at 60 °C |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
| 最大波長(λmax) | 248nm(MeOH)(lit.) |
| Merck | 14,6438 |
| CAS 數(shù)據(jù)庫 | 82752-99-6(CAS DataBase Reference) |
Nefazodone hydrochloride (BMY-13754) 是一種強效和選擇性的 5HT2A (Ki=5.8 nM) 拮抗劑，對 5-HT 和去甲腎上腺素攝取具有中度抑制作用 (IC50 分別為 290 和 300 nM)。Nefazodone hydrochloride 是一種苯哌嗪類抗抑郁藥，具有微弱的 α-腎上腺素阻斷活性。
|
5-HT 2A Receptor 5.8 nM (Ki) |
α1-adrenergic receptor
|
Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.
安全信息
| 安全說明 | 22-24/25 |
|---|---|
| 危險品運輸編號 | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS號 | XZ5483009 |
| 海關(guān)編碼 | 2933595960 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-B1396 | 萘法唑酮鹽酸鹽 Nefazodone hydrochloride | 82752-99-6 | 5 mg | 437元 |
| 2025/02/08 | HY-B1396 | 萘法唑酮鹽酸鹽 Nefazodone hydrochloride | 82752-99-6 | 10mg | 700元 |