鹽酸胺苯吖啶
中文名稱 | 鹽酸胺苯吖啶 |
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中文同義詞 | 鹽酸胺苯吖啶,安吖啶,胺苯吖啶,N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺;安吖啶鹽酸鹽;N-[4-(9-吖啶氨基)-3-甲氧苯基]甲基磺酰胺鹽酸鹽;鹽酸胺苯吖啶;N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺;安沙克林;胺苯丫啶;鹽酸胺苯吖啶, ≥98% (HPLC) |
英文名稱 | Amsacrine hydrochloride |
英文同義詞 | m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride;Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride;Methanesulfon-m-anisidide 4'-(9-acridinylamino)-;Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride;4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE;M-AMSA HYDROCHLORIDE;M-AMSA, HCL;Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride |
CAS號 | 54301-15-4 |
分子式 | C21H20ClN3O3S |
分子量 | 429.92 |
EINECS號 | 637-255-8 |
相關(guān)類別 | 細(xì)胞信號和神經(jīng)生物學(xué);細(xì)胞生物學(xué) |
Mol文件 | 54301-15-4.mol |
結(jié)構(gòu)式 |
鹽酸胺苯吖啶 性質(zhì)
熔點(diǎn) | 197-199 °C(lit.) |
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儲存條件 | Refrigerator |
溶解度 | 加熱和超聲處理時在DMSO中的溶解度10 mg/mL |
形態(tài) | 粉末 |
顏色 | 紅色至棕色 |
Target | Value |
Topo II
() |
Amsacrine (mAMSA) blocks HERG currents in HEK 293 cells and Xenopus oocytes in a concentration-dependent manner, with IC 50 values of 209.4 nM and 2.0 μM, respectively. Amsacrine (mAMSA) causes a negative shift in the voltage dependence of both activation (?7.6 mV) and inactivation (?7.6 mV). HERG current block by Amsacrine (mAMSA) is not frequency dependent. In vitro studies of normal human lymphocytes with various concentrations of Amsacrine (mAMSA), show both increased levels of chromosomal aberrations, ranging from 8% to 100%, and increase SCEs, ranging from 1.5 times the normal at the lowest concentration studied (0.005 μg/mL) to 12 times the normal (0.25 μg/mL). Amsacrine (mAMSA)-induced apoptosis of U937 cells is characterized by caspase-9 and caspase-3 activation, increased intracellular Ca 2+ concentration, mitochondrial depolarization, and MCL1 down-regulation. Amsacrine induces MCL1 down-regulation by decreasing its stability. Further, amsacrine-treated U937 cells show AKT degradation and Ca 2+ -mediated ERK inactivation.
In animals treated with different doses of amsacrine (0.5-12 mg/kg), the frequencies of micronucleated polychromatic erythrocytes increase significantly after treatment with 9 and 12 mg/kg. Furthermore, the present study demonstrates for the first time that Amsacrine (mAMSA) has high incidences of clastogenicity and low incidences of aneugenicity whereas nocodazole has high incidences of aneugenicity and low incidences of clastogenicity during mitotic phases in vivo.
安全信息
危險品標(biāo)志 | T |
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危險類別碼 | 25-36/37/38 |
安全說明 | 26-45 |
危險品運(yùn)輸編號 | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS號 | PB1081000 |
海關(guān)編碼 | 2933.99.8290 |
危險等級 | 6.1(b) |
包裝類別 | III |
鹽酸胺苯吖啶 化學(xué)藥品說明書
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2024/11/08 | HY-13551A | Amsacrine hydrochloride | 5 mg | 360元 | |
2024/11/08 | HY-13551A | 鹽酸胺苯吖啶 Amsacrine hydrochloride | 54301-15-4 | 10mM * 1mLin DMSO | 396元 |