達(dá)格列酮
| 中文名稱 | 達(dá)格列酮 |
|---|---|
| 中文同義詞 | 達(dá)格列酮;化合物 T22708 |
| 英文名稱 | darglitazone |
| 英文同義詞 | darglitazone;2,4-Thiazolidinedione, 5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-;5-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl]methyl]-1,3-thiazolidine-2,4-dione;oral,UCP2,corticosterone,PPAR-γ,CP86325,Darglitazone,Diabetes,CP-86325,Inhibitor,PPAR,inhibit,Peroxisome proliferator-activated receptors,CP 86325,thiazolidinedione |
| CAS號 | 141200-24-0 |
| 分子式 | C23H20N2O4S |
| 分子量 | 420.48 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 141200-24-0.mol |
| 結(jié)構(gòu)式 |  |
達(dá)格列酮 性質(zhì)
| 密度 | 1.306±0.06 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | DMSO:20.0(最大濃度 mg/mL);47.56(最大濃度 mM) DMF:20.0(最大濃度 mg/mL);47.56(最大濃度 mM) |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | 6.22±0.50(Predicted) |
| 顏色 | 白色至淺黃色 |
|
PPAR-γ
|
In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), within 4 h of exposing these cells to 30 μM Darglitazone, there is an increase in uncoupling protein 2 (UCP2) mRNA which reached a plateau of 5-10 times the basal in about 8 h. Darglitazone can stimulate the expression of UCP2 gene probably via PPAR-γ.
Darglitazone treatment restores euglycemia and normalized elevated corticosterone, triglycerides, and very-low-density lipoprotein levels. Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24?h of recovery. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult.
| Animal Model: | Male diabetic ob/ob mice |
| Dosage: | 1?mg/kg |
| Administration: | Oral administration; daily; for 7 days |
| Result: | Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-120160 | 達(dá)格列酮 Darglitazone | 141200-24-0 | 1 mg | 350元 |
| 2025/02/08 | HY-120160 | 達(dá)格列酮 Darglitazone | 141200-24-0 | 5 mg | 780元 |