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| | beta-Cyclodextrin hydrate Basic information |
| Product Name: | beta-Cyclodextrin hydrate | | Synonyms: | BETA-SCHARDINGER DEXTRIN;BETA-SHARDINGER DEXTRIN;BETA-CYCLODEXTRIN HYDRATE;CD;CYCLOHEPTAAMYLOSE;CYCLOHEPTAAMYLOSE HYDRATE;á-cyclodextrin hydrate;schardinger á-dextrin | | CAS: | 68168-23-0 | | MF: | C42H70O35 | | MW: | 1134.98 | | EINECS: | 231-493-2 | | Product Categories: | | | Mol File: | 68168-23-0.mol |  |
| | beta-Cyclodextrin hydrate Chemical Properties |
| Melting point | >260 °C (dec.)(lit.) | | alpha | 161 º (c=1, H2O 25 ºC) | | storage temp. | Refrigerator | | solubility | Water (Slightly) | | form | Crystalline Powder | | color | White | | optical activity | [α]20/D +142°, c = 1 in H2O (Dry basis) | | Water Solubility | 18.5 g/L (25 ºC) | | Merck | 14,2718 | | BRN | 5915513 |
| Safety Statements | 24/25 | | WGK Germany | 2 | | RTECS | GU2293000 | | TSCA | Yes | | HS Code | 35051000 |
| | beta-Cyclodextrin hydrate Usage And Synthesis |
| Description | β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility. | | Chemical Properties | white crystalline powder | | Uses | beta-Cyclodextrin hydrate forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins. It is used in pharmaceutical research, as pharmaceutical intermediates and also as chemical reagents. | | General Description | β-cyclodextrin (β-CD), a well-known macrocyclic oligosaccharide member of the CD family, is composed of seven D-glucose units connected via α(1→4) glycosidic bonds. Its ability to form several inclusion complexes with organic as well as inorganic compounds makes it a potential candidate in solid and solution state determinations. | | Purification Methods | Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.] |
| | beta-Cyclodextrin hydrate Preparation Products And Raw materials |
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