Roxatidine manufacturers
- Roxatidine
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- $0.00 / 1kg
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2025-03-07
- CAS:78273-80-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- Roxatidine
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- $1.00 / 1g
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2025-01-03
- CAS:78273-80-0
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 50tons
- Roxatidine
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- $0.00 / 1KG
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2024-10-29
- CAS:78273-80-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | Roxatidine Basic information |
| Product Name: | Roxatidine | | Synonyms: | ROXATIDINE;n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide;2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide;2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide;ROXATIDINE ENTERPRISE STANDARD;RoxatidineAcetateHclBase;ROXATIDINE(SUBJECTTOPATENTFREE);desacetyl-TZU-0460 | | CAS: | 78273-80-0 | | MF: | C17H26N2O3 | | MW: | 306.4 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 78273-80-0.mol |  |
| | Roxatidine Chemical Properties |
| Melting point | 59-60 °C | | Boiling point | 524.3±45.0 °C(Predicted) | | density | 1.137±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 25 mg/ml). | | pka | 13.34±0.10(Predicted) | | form | oil | | color | Colorless to pale yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 78273-80-0(CAS DataBase Reference) |
| | Roxatidine Usage And Synthesis |
| Description | Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4 | | Uses | Anti-ulcerative. | | References | 1) Mills and Wood (1989),?The pharmacology of histamine H2-receptor antagonists; Methods Find. Exp. Clin. Pharmacol., 11 Suppl. 1?87
2) Cho?et al. (2011), Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages; J. Cell. Biochem.,?112?3648
3) Imaeda?et al.?(2011),?Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia; J. Gastroenterol.,?46?1267
4) Ze?et al. (2017),?Roxatidine Attenuates Degradation of Extracellular Matrix;?Biomed. Pharmacother.,?95?1156 |
| | Roxatidine Preparation Products And Raw materials |
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