山竹子素
| 中文名稱 | 山竹子素 |
|---|---|
| 中文同義詞 | 山竹子素;GARCINOL,HAT P300 AND PCAF抑制劑;山竹子素,10 MM DMSO 溶液 |
| 英文名稱 | garcinol |
| 英文同義詞 | (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione;Camboginol;(1R,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxy-methylidene]-8,8-dimethyl-1,7-bis(3-methylbut-2-enyl)-5-[(2S)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione;garcinol;(1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)-;802;CP-54 |
| CAS號(hào) | 78824-30-3 |
| 分子式 | C38H50O6 |
| 分子量 | 602.8 |
| EINECS號(hào) | 200-258-5 |
| 相關(guān)類別 | 植物提取物;中藥對(duì)照品;標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;色譜純 |
| Mol文件 | 78824-30-3.mol |
| 結(jié)構(gòu)式 |  |
山竹子素 性質(zhì)
| 熔點(diǎn) | 132 °C |
|---|---|
| 沸點(diǎn) | 710.8±60.0 °C(Predicted) |
| 密度 | 1.114±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | 可溶于DMSO（高達(dá)25mg/ml）或乙醇（高達(dá)25mg/ml）。 |
| 酸度系數(shù)(pKa) | 4.50±1.00(Predicted) |
| 形態(tài) | 黃色固體 |
| 顏色 | 粘黃色 |
| 穩(wěn)定性 | DMSO中的溶液可在-20°下穩(wěn)定儲(chǔ)存1個(gè)月。Garcinol容易氧化。防止暴露在空氣中。 |
| LogP | 11.546 (est) |
Garcinol 是一種從印度藤黃提取的聚異戊二烯基二苯甲酮，對(duì)乙酰膽堿酯酶 (AChE) 和丁酰膽堿酯酶 (BChE) 具有抗膽堿酯酶的特性，IC50 分別為 0.66 μM 和 7.39 μM。Garcinol 還抑制組蛋白乙酰轉(zhuǎn)移酶 (HATs, IC50=7 μM) 和 p300/CPB 相關(guān)因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。
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Human Endogenous Metabolite
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Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells.
Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
Cell Proliferation Assay
| Cell Line: | CAL27 and UMSCC1 cells |
| Concentration: | 10, 25, 50 μM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner. |
Apoptosis Analysis
| Cell Line: | CAL27 and UMSCC1 cells |
| Concentration: | 10, 25, 50 μM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Induced apoptosis in HNSCC cells. |
Western Blot Analysis
| Cell Line: | CAL27 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 2, 4, 6 hours |
| Result: | Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner. |
Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth.
| Animal Model: | Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors |
| Dosage: | 1 and 2 mg/kg |
| Administration: | I.p.; five times/week for 4 consecutive weeks |
| Result: | Induced significant inhibition of tumor growth. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-107569 | 山竹子素 Garcinol | 78824-30-3 | 1mg | 800元 |
| 2025/02/08 | HY-107569 | 山竹子素 Garcinol | 78824-30-3 | 5mg | 2450元 |