3-(溴乙酸?；?丙酸琥珀酰亞胺酯
| 中文名稱 | 3-(溴乙酸?；?丙酸琥珀酰亞胺酯 |
|---|---|
| 中文同義詞 | 3-(溴乙酸?；?丙酸琥珀酰亞胺酯;琥珀酰亞胺基 3-(溴乙酰氨基)丙酸酯;2,5-DIOXOPYRROLIDIN-1-YL 3-(3-BROMOACETAMIDO)PROPANOATE;2,5-二氧代吡咯烷-1-基 3-(2-溴乙酰氨基)丙酸酯;3-(溴乙酰胺基)琥珀酰亞胺基丙酸酯;化合物 N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE |
| 英文名稱 | N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE |
| 英文同義詞 | 2-BroMo-N-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]acetaMide;SucciniMidyl 3-(broMoacetaMido)propionate(SBAP);SBAP;SUCCINIMIDYL 3-[BROMOACETAMIDO]PROPIONATE;N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE;Succinimidyl 3-(bromoacetamido)propionate≥ 98% (HPLC);2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate;β-Alanine, N-(2-bromoacetyl)-, 2,5-dioxo-1-pyrrolidinyl ester |
| CAS號(hào) | 57159-62-3 |
| 分子式 | C9H11BrN2O5 |
| 分子量 | 307.1 |
| EINECS號(hào) | |
| 相關(guān)類別 | MTS and Sulfhydryl Active Reagents;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents |
| Mol文件 | 57159-62-3.mol |
| 結(jié)構(gòu)式 |  |
3-(溴乙酸?；?丙酸琥珀酰亞胺酯 性質(zhì)
| 熔點(diǎn) | 93-94°C |
|---|---|
| 密度 | 1.69±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于氯仿（輕微，加熱），甲醇（輕微） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 12.96±0.46(Predicted) |
| 顏色 | 灰白色至白色蠟狀 |
| CAS 數(shù)據(jù)庫(kù) | 57159-62-3 |
N-Succinimidyl 3-(Bromoacetamido)propionate 是一種 PROTAC linker，屬于 PEG 類?？捎糜诤铣蒔ROTAC分子。N-Succinimidyl 3-(Bromoacetamido)propionate 也是一種可降解 (cleavable) 的 ADC linker，可用于合成抗體偶聯(lián)藥物 (ADC)。
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PEGs
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Alkyl/ether
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Cleavable
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
安全信息
| 海關(guān)編碼 | 2933998090 |
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