4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
生物活性靶點(diǎn)體外研究體內(nèi)研究 用途與合成方法 MSDS 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide |
|---|---|
| 中文同義詞 | 化合物 T17007;化合物 TC-MPS1-12 |
| 英文名稱 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide |
| 英文同義詞 | TC Mps1 12;4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide;TCMps112,TC-Mps-1-12,TC Mps1 12;Benzamide, 4-[[4-amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]- |
| CAS號(hào) | 1206170-62-8 |
| 分子式 | C17H20N6O |
| 分子量 | 324.38 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品 |
| Mol文件 | 1206170-62-8.mol |
| 結(jié)構(gòu)式 | ![4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide 結(jié)構(gòu)式](CAS/20200119/GIF/1206170-62-8.gif) |
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide 性質(zhì)
| 沸點(diǎn) | 601.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.28±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | <32.44mg/ml，溶于 DMSO； <6.49mg/ml，乙醇中 |
| 酸度系數(shù)(pKa) | 16.23±0.50(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
TC-Mps1-12 是一種高效、選擇性的 Mps1 抑制劑，其 IC50 值為 6.4 nM。
IC50: 6.4 nM (Mps1)
TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay.
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC
50
values of 0.84 μM.
Cell Viability Assay
| Cell Line: | 549 cells |
| Concentration: | |
| Incubation Time: | 72 hours |
| Result: | Inhibited the growth of cells in a dose-dependent manner and with an IC 50 values of 0.84 μM. |
TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss.
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg.
| Animal Model: | A549 mouse xenograft model |
| Dosage: | 25 mg/kg, 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration; once daily; for 19 days |
| Result: | Inhibited the growth of A549 cells in a dose-dependent manner. |
| Animal Model: | A549 mouse xenograft model (pharmacokinetic ) |
| Dosage: | 25 mg/kg |
| Administration: | Oral administration |
| Result: | C max = 3542 ng/mL, AUC = 6604 ng h/mL |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12 | 1206170-62-8 | 1mg | 1750元 |
| 2024/11/08 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12 | 1206170-62-8 | 5mg | 5200元 |