4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
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- CAS號:
- 1206170-62-8
- 英文名:
- 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
- 英文別名:
- TC Mps1 12;TCMps112,TC-Mps-1-12,TC Mps1 12;4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide;Benzamide, 4-[[4-amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]-
- 中文名:
- 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
- 中文別名:
- 化合物 T17007;化合物 TC-MPS1-12
- CBNumber:
- CB04902737
- 分子式:
- C17H20N6O
- 分子量:
- 324.38
- MOL File:
- 1206170-62-8.mol
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4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide化學(xué)性質(zhì)
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沸點:
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601.0±55.0 °C(Predicted)
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密度:
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1.28±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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<32.44mg/ml in DMSO; <6.49mg/ml in ethanol
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酸度系數(shù)(pKa):
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16.23±0.50(Predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide性質(zhì)、用途與生產(chǎn)工藝
TC-Mps1-12 是一種高效、選擇性的 Mps1 抑制劑，其 IC50 值為 6.4 nM。
TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay.
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC
50
values of 0.84 μM.
Cell Viability Assay
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Cell Line:
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549 cells
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Concentration:
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Incubation Time:
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72 hours
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Result:
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Inhibited the growth of cells in a dose-dependent manner and with an IC
50
values of 0.84 μM.
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TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss.
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg.
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Animal Model:
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A549 mouse xenograft model
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Dosage:
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25 mg/kg, 50 mg/kg, 100 mg/kg
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Administration:
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Oral administration; once daily; for 19 days
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Result:
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Inhibited the growth of A549 cells in a dose-dependent manner.
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Animal Model:
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A549 mouse xenograft model (pharmacokinetic )
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Dosage:
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25 mg/kg
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Administration:
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Oral administration
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Result:
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C
max
= 3542 ng/mL, AUC = 6604 ng h/mL
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4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2024/11/08 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
TC-Mps1-12 | 1206170-62-8 | 1mg | 1750元 |
| 2024/11/08 | HY-110115 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
TC-Mps1-12 | 1206170-62-8 | 5mg | 5200元 |
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
生產(chǎn)廠家
1206170-62-8, 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide 相關(guān)搜索:
- 抑制劑
- 標準品
- 化合物 TC-MPS1-12
- 化合物 T17007
- 1206170-62-8
- Benzamide, 4-[[4-amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]-
- TCMps112,TC-Mps-1-12,TC Mps1 12
- 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
- TC Mps1 12