N5,N6-ビス(2-フルオロフェニル)-[1,2,5]オキサジアゾロ[3,4-b]ピラジン-5,6-ジアミン
![N5,N6-ビス(2-フルオロフェニル)-[1,2,5]オキサジアゾロ[3,4-b]ピラジン-5,6-ジアミン price.](/CAS/20200611/GIF/210302-17-3.gif)
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- ￥21900 - ￥87400
- 化學(xué)名: N5,N6-ビス(2-フルオロフェニル)-[1,2,5]オキサジアゾロ[3,4-b]ピラジン-5,6-ジアミン
- 英語(yǔ)名: BAM15
- 別名:N5,N6-ビス(2-フルオロフェニル)-[1,2,5]オキサジアゾロ[3,4-b]ピラジン-5,6-ジアミン
- CAS番號(hào): 210302-17-3
- 分子式: C16H10F2N6O
- 分子量: 340.29
- EINECS:201-118-7
- MDL Number:MFCD00373912
2物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML1760
- 製品説明 ≥98% (HPLC)
- 英語(yǔ)製品説明BAM15 ≥98% (HPLC)
- 包裝単位25mg
- 価格￥87400
- 更新しました2024-03-01
- 購(gòu)入
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)SML1760
- 製品説明 ≥98% (HPLC)
- 英語(yǔ)製品説明BAM15 ≥98% (HPLC)
- 包裝単位5mg
- 価格￥21900
- 更新しました2024-03-01
- 購(gòu)入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購(gòu)入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML1760 | ≥98% (HPLC) BAM15 ≥98% (HPLC) |
25mg | ￥87400 | 2024-03-01 | 購(gòu)入 |
| Sigma-Aldrich Japan | SML1760 | ≥98% (HPLC) BAM15 ≥98% (HPLC) |
5mg | ￥21900 | 2024-03-01 | 購(gòu)入 |
プロパティ
沸點(diǎn) :421.7±55.0 °C(Predicted)
比重(密度) :1.548±0.06 g/cm3(Predicted)
貯蔵溫度 :-20°C
溶解性 :Soluble in DMSO (35 mg/ml)
酸解離定數(shù)(Pka) :-2.40±0.50(Predicted)
外見(jiàn) :powder
色 :white to beige
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
比重(密度) :1.548±0.06 g/cm3(Predicted)
貯蔵溫度 :-20°C
溶解性 :Soluble in DMSO (35 mg/ml)
酸解離定數(shù)(Pka) :-2.40±0.50(Predicted)
外見(jiàn) :powder
色 :white to beige
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
安全情報(bào)
| 絵表示(GHS): |
  
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| 注意喚起語(yǔ): | Danger | |||||||||||||||||||||||||||||||||||
| 危険有害性情報(bào): |
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| 注意書(shū)き: |
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説明
Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury. In comparison to FCCP , 1-10 μM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.関連商品価格
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