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ChemicalBook >> CAS DataBase List >> Pictilisib

Pictilisib

Pictilisib price.
  • $49 - $3563.2
  • Product name: Pictilisib
  • CAS: 957054-30-7
  • MF: C23H27N7O3S2
  • MW: 513.64
  • EINECS:1312995-182-4
  • MDL Number:MFCD11616196
  • Synonyms:Pictilisib;Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-;GDC-0941;GDC-0941 free base;2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine;GDC-0941 bismesylate;2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine;4-(2-(1H-Indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]
35 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AstaTech
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
Package
  • 1MG
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 0.25G
  • 250mg
  • 500mg
  • 1G
  • 2g
  • 0.25/ G
  • 1/ G
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1041-M100
  • Product descriptionGDC-0941 ≥95%
  • Packaging100mg
  • Price$653
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7409
  • Product descriptionGDC-0941
  • Packaging25mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000294
  • Product descriptionGDC-0941 95.00%
  • Packaging1MG
  • Price$203.7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000294
  • Product descriptionGDC-0941 95.00%
  • Packaging5MG
  • Price$756.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000294
  • Product descriptionGDC-0941 95.00%
  • Packaging25MG
  • Price$1097.25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8210
  • Product descriptionGDC-0941
  • Packaging50mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60067
  • Product descriptionPictilisib(GDC-0941) ≥98%
  • Packaging10mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerAstaTech
  • Product number51356
  • Product description4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 97%
  • Packaging1/ G
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAstaTech
  • Product number51356
  • Product description4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE
  • Packaging1G
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAstaTech
  • Product number51356
  • Product description4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 97%
  • Packaging0.25/ G
  • Price$335
  • Updated2021-12-16
  • Buy
  • ManufacturerAstaTech
  • Product number51356
  • Product description4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE
  • Packaging0.25G
  • Price$335
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61040
  • Product descriptionGDC-0941, Free Base >99% pure
  • Packaging25mg
  • Price$307.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61040
  • Product descriptionGDC-0941, Free Base >99% pure
  • Packaging50mg
  • Price$343.4
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb61040
  • Product descriptionGDC-0941, Free Base >99% pure
  • Packaging100mg
  • Price$493
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb61040
  • Product descriptionGDC-0941, Free Base >99% pure
  • Packaging200mg
  • Price$571.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154703
  • Product descriptionGDC0941 >99%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1041-M100 GDC-0941 ≥95% 100mg $653 2021-12-16 Buy
AK Scientific X7409 GDC-0941 25mg $49 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000294 GDC-0941 95.00% 1MG $203.7 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000294 GDC-0941 95.00% 5MG $756.25 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000294 GDC-0941 95.00% 25MG $1097.25 2021-12-16 Buy
ApexBio Technology A8210 GDC-0941 50mg $75 2021-12-16 Buy
Arctom CFN60067 Pictilisib(GDC-0941) ≥98% 10mg $118 2021-12-16 Buy
AstaTech 51356 4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 97% 1/ G $550 2021-12-16 Buy
AstaTech 51356 4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 1G $550 2021-12-16 Buy
AstaTech 51356 4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 97% 0.25/ G $335 2021-12-16 Buy
AstaTech 51356 4-(2-(1H-INDAZOL-4-YL)-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 0.25G $335 2021-12-16 Buy
Biorbyt Ltd orb61040 GDC-0941, Free Base >99% pure 25mg $307.7 2021-12-16 Buy
Biorbyt Ltd orb61040 GDC-0941, Free Base >99% pure 50mg $343.4 2021-12-16 Buy
Biorbyt Ltd orb61040 GDC-0941, Free Base >99% pure 100mg $493 2021-12-16 Buy
Biorbyt Ltd orb61040 GDC-0941, Free Base >99% pure 200mg $571.2 2021-12-16 Buy
Biorbyt Ltd orb154703 GDC0941 >99% 100mg $615.4 2021-12-16 Buy

Properties

Melting point :>200oC (dec.)
Density :1.53±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :White powder solid.
pka :12.22±0.40(Predicted)
color :White/off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively. It is much less effective against class II-IV isoforms of PI3K and against mTOR. GDC-0941 inhibits the growth of certain types of cancer cells and blocks signaling through PI3K to Akt, both in cells and in vivo.

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