ChemicalBook >> CAS DataBase List >>Pictilisib

Pictilisib

Pictilisib structure

CAS No.: 957054-30-7

Chemical Name:: Pictilisib

Synonyms: CS-23;RG7321;GDC-01;GNE0941;GDC-0941;GNE 0941;GNE-0941;Pictilisib;pictrelisib;GDC-0941 Base

CBNumber:: CB41872141

Molecular Formula:: C23H27N7O3S2

Molecular Weight:: 513.64

MDL Number:: MFCD11616196

MOL File:: 957054-30-7.mol

Last updated:2025-01-27 09:38:02

Request For Quotation

Pictilisib Properties

Melting point	>200oC (dec.)
Density	1.53±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (>25 mg/ml)
pka	12.22±0.40(Predicted)
form	White powder solid.
color	White/off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII	ICY00EMP8P
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code	29350090

Pictilisib price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11600	GDC-0941 ≥98%	957054-30-7	10mg	$134	2024-03-01	Buy
Cayman Chemical	11600	GDC-0941 ≥98%	957054-30-7	50mg	$333	2024-03-01	Buy
Cayman Chemical	11600	GDC-0941 ≥98%	957054-30-7	100mg	$531	2024-03-01	Buy
Biorbyt Ltd	orb61040	GDC-0941, Free Base >99% pure	957054-30-7	100mg	$493	2021-12-16	Buy
Biorbyt Ltd	orb61040	GDC-0941, Free Base >99% pure	957054-30-7	50mg	$343.4	2021-12-16	Buy

Product number	Packaging	Price	Buy
11600	10mg	$134	Buy
11600	50mg	$333	Buy
11600	100mg	$531	Buy
orb61040	100mg	$493	Buy
orb61040	50mg	$343.4	Buy

Pictilisib Chemical Properties,Uses,Production

Description

GDC-0941/Pictilisib (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2?? GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3?Currently in clinical trials.4

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.

Definition

ChEBI: A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.

target

PI3Kα

References

1) Folkes?et al.?(2008),?The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer;? J.?Med. Chem.,?51?5522 2) Raynaud?et al. (2009),?Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinase: from PI-103 through PI-540, PI620 to the oral agent GDC-0941; Mol. Cancer Ther.,?8?1725 3) Knapp et al. (2013),?A public-private partnership to unlock the untargeted kinome; Nat. Chem. Biol.,?9?3 4) Sarker?et al. (2015),?First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors; Clin. Cancer Res.,?21?77

Pictilisib Preparation Products And Raw materials

Raw materials

Preparation Products

Pictilisib Suppliers

Global( 218)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33025	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29867	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
TargetMol Chemicals Inc.	58

View Lastest Price from Pictilisib manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Pictilisib 957054-30-7	US $38.00-64.00 / mg		99.97%	10g	TargetMol Chemicals Inc.
	2019-07-06	Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- 957054-30-7	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

Pictilisib
957054-30-7
US $38.00-64.00 / mg
99.97%
TargetMol Chemicals Inc.

Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-
957054-30-7
US $2.00 / kg
99%
Career Henan Chemical Co

Pictilisib Spectrum

Pictilisib(957054-30-7)¹HNMR

957054-30-7(Pictilisib)Related Search:

Motesanib DL-Malic acid Everolimus MK-2206 2HCl CAL-101

Trametinib PLX4032 BEZ235 (NVP-BEZ235, Dactolisib) 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE

NSC 23766 TETRAHYDROCHLORIDE NSC697923 MIF Antagonist, ISO-1 GSK-3β Inhibitor XVIII JNJ-10198409

Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

1of4

Pictilisib Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- GDC-0941 GDC-0941 free base 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941 bismesylate 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine 4-(2-(1H-Indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d] 4-{6-[(4-Methanesulfonylpiperazin-1-yl)Methyl]-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidin-2-yl}-1H-indazole 4-(2-(1H-indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]pyriMidin-4-yl)Morpholine 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrim 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine RG7321 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941 GDC-0941 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941 (Pictilisib) pictrelisib GDC-0941;GDC 0941;GDC0941 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]py GDC-0941, >=98% Pictilisib, 98%, a potent inhibitor of PI3Kα/δ GDC0941; GDC 0941; RG7321 GDC-0941;GDC 0941 CS-23 GDC-01 Pictilisib (GDC0941, RG7321, GNE0941)) 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)me... PI 3-K Inhibitor XXI GDC-0941 GDC0941 GNE 0941 GNE0941 GNE-0941 GDC-0941 Base Pictilisib, 10 mM in DMSO 957054-30-7 C23H27N7O3S2 An inhibitor of class I PI3 kinase (PI3K). Inhibitors Akt mTOR PI3K

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天