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ChemicalBook >> CAS DataBase List >> LY411575

LY411575

LY411575 price.
  • $37 - $4023.9
  • Product name: LY411575
  • CAS: 209984-57-6
  • MF: C26H23F2N3O4
  • MW: 479.48
  • EINECS:
  • MDL Number:MFCD09832551
  • Synonyms:LY411575;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide;(S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide;Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575;LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide;LSN-411575;N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
41 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Ark Pharm
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 0.5MG
  • 1MG
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2530AH
  • Product description(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide
  • Packaging5mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2530AH
  • Product description(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA140795
  • Product descriptionLY411575 98+%
  • Packaging5mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA140795
  • Product descriptionLY411575 98+%
  • Packaging10mg
  • Price$82
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA140795
  • Product descriptionLY411575 98+%
  • Packaging25mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA140795
  • Product descriptionLY411575 98+%
  • Packaging50mg
  • Price$178
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA140795
  • Product descriptionLY411575 98+%
  • Packaging100mg
  • Price$241
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013693
  • Product description(AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00%
  • Packaging1MG
  • Price$415.52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013693
  • Product description(AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00%
  • Packaging0.5MG
  • Price$407.76
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4019
  • Product descriptionLY-411575
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS448748
  • Product descriptionLY411575 ≥98%
  • Packaging5mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS448748
  • Product descriptionLY411575 ≥98%
  • Packaging10mg
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS448748
  • Product descriptionLY411575 ≥98%
  • Packaging25mg
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS448748
  • Product descriptionLY411575 ≥98%
  • Packaging50mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS448748
  • Product descriptionLY411575 ≥98%
  • Packaging100mg
  • Price$239
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000077461
  • Product descriptionLY411575 98+%
  • Packaging5mg
  • Price$144
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2530AH (2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide 5mg $132 2021-12-16 Buy
AK Scientific 2530AH (2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][3]benzazepin-7-yl]propanamide 10mg $170 2021-12-16 Buy
Ambeed A140795 LY411575 98+% 5mg $54 2021-12-16 Buy
Ambeed A140795 LY411575 98+% 10mg $82 2021-12-16 Buy
Ambeed A140795 LY411575 98+% 25mg $137 2021-12-16 Buy
Ambeed A140795 LY411575 98+% 50mg $178 2021-12-16 Buy
Ambeed A140795 LY411575 98+% 100mg $241 2021-12-16 Buy
American Custom Chemicals Corporation API0013693 (AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00% 1MG $415.52 2021-12-16 Buy
American Custom Chemicals Corporation API0013693 (AS)-N-[(1S)-2-[[(7S)-6,7-DIHYDRO-5-METHYL-6-OXO-5H-DIBENZ[B,D]AZEPIN-7-YL]AMINO]-1-METHYL-2-OXOETHYL]-3,5-DIFLUORO-ALPHA-HYDROXYBENZENEACETAMIDE 95.00% 0.5MG $407.76 2021-12-16 Buy
ApexBio Technology A4019 LY-411575 10mM(in 1mL DMSO) $130 2021-12-16 Buy
Arctom AS448748 LY411575 ≥98% 5mg $53 2021-12-16 Buy
Arctom AS448748 LY411575 ≥98% 10mg $81 2021-12-16 Buy
Arctom AS448748 LY411575 ≥98% 25mg $136 2021-12-16 Buy
Arctom AS448748 LY411575 ≥98% 50mg $176 2021-12-16 Buy
Arctom AS448748 LY411575 ≥98% 100mg $239 2021-12-16 Buy
Ark Pharm P000077461 LY411575 98+% 5mg $144 2021-12-16 Buy

Properties

Boiling point :836.0±65.0 °C(Predicted)
Density :1.40
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :11.79±0.20(Predicted)
color :white to beige
InChIKey :ULSSJYNJIZWPSB-CVRXJBIPSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

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