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ChemicalBook >> CAS DataBase List >> Semagacestat

Semagacestat

Semagacestat price.
  • $28 - $2395.3
  • Product name: Semagacestat
  • CAS: 425386-60-3
  • MF: C19H27N3O4
  • MW: 361.44
  • EINECS:1592732-453-0
  • MDL Number:MFCD09970409
  • Synonyms:(2S)-2-HYDROXY-3-METHYL-N-[(2S)-1-{[(1S)-3-METHYL-2-OXO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPIN-1-YL]AMINO}-1-OXOPROPAN-2-YL]BUTANAMIDE;semagacestat;Butanamide, 2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5- tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-, (2S)-;(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide;Semagacestat/LY-450139;Unii-3yn0602W4w;LY450139(Semagacestat);2-hydroxy-3-Methyl-N-[(1S)-1-Methyl-2-oxo-2-[[(1S)-2
41 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Tocris
  • TRC
  • Usbiological
Package
  • 25
  • 1mg
  • 5mg
  • 5
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberX7560
  • Product descriptionSemagacestat
  • Packaging1mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892738
  • Product descriptionSemagacestat 98+%
  • Packaging1mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892738
  • Product descriptionSemagacestat 98+%
  • Packaging5mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892738
  • Product descriptionSemagacestat 98+%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892738
  • Product descriptionSemagacestat 98+%
  • Packaging50mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892738
  • Product descriptionSemagacestat 98+%
  • Packaging100mg
  • Price$256
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000737
  • Product descriptionLY-450139 95.00%
  • Packaging5MG
  • Price$494
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000737
  • Product descriptionLY-450139 95.00%
  • Packaging10MG
  • Price$528
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000737
  • Product descriptionLY-450139 95.00%
  • Packaging100MG
  • Price$1038
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8190
  • Product descriptionSemagacestat(LY450139)
  • Packaging200mg
  • Price$1500
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60448
  • Product descriptionSemagacestat ≥98%
  • Packaging10mg
  • Price$358
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181318
  • Product descriptionSemagacestat >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181318
  • Product descriptionSemagacestat >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181318
  • Product descriptionSemagacestat >98%
  • Packaging1000mg
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS34135
  • Product descriptionSemagacestat
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS34135
  • Product descriptionSemagacestat
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7560 Semagacestat 1mg $28 2021-12-16 Buy
Ambeed A892738 Semagacestat 98+% 1mg $35 2021-12-16 Buy
Ambeed A892738 Semagacestat 98+% 5mg $59 2021-12-16 Buy
Ambeed A892738 Semagacestat 98+% 10mg $108 2021-12-16 Buy
Ambeed A892738 Semagacestat 98+% 50mg $182 2021-12-16 Buy
Ambeed A892738 Semagacestat 98+% 100mg $256 2021-12-16 Buy
American Custom Chemicals Corporation INB0000737 LY-450139 95.00% 5MG $494 2021-12-16 Buy
American Custom Chemicals Corporation INB0000737 LY-450139 95.00% 10MG $528 2021-12-16 Buy
American Custom Chemicals Corporation INB0000737 LY-450139 95.00% 100MG $1038 2021-12-16 Buy
ApexBio Technology A8190 Semagacestat(LY450139) 200mg $1500 2021-12-16 Buy
Arctom CFN60448 Semagacestat ≥98% 10mg $358 2021-12-16 Buy
Biorbyt Ltd orb181318 Semagacestat >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181318 Semagacestat >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb181318 Semagacestat >98% 1000mg $2395.3 2021-12-16 Buy
Biosynth Carbosynth FS34135 Semagacestat 50mg $612.5 2021-12-16 Buy
Biosynth Carbosynth FS34135 Semagacestat 10mg $175 2021-12-16 Buy

Properties

Melting point :208-212 °C
Boiling point :681.9±55.0 °C(Predicted)
Density :1.22
Flash point :366.2℃
storage temp. :2-8°C
solubility :DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form :Solid
pka :12.97±0.20(Predicted)
color :White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. Semagacestat is a potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion. Although semagacestat does not improve cognitive status in humans, it is useful as a pan γ-secretase inhibitor for research purposes.

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