Geldanamycin
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- $14 - $2363
- Product name: Geldanamycin
- CAS: 30562-34-6
- MF: C29H40N2O9
- MW: 560.64
- EINECS:999-999-2
- MDL Number:MFCD00274570
- Synonyms:CP-122634;9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate;NSC 212518;GELDANAMYCIN FROM STRE;GeldanaMycin, froM StreptoMyces hygroscopicus var geldanus;GeldanaMycin froM StreptoMyces hygroscopi;2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate;Geldanamycin [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
55 prices
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Brand
- Adipogen Life Sciences
- AK Scientific
- Alfa Aesar
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 2.5mg
- 10mM(in 1mL DMSO)
- 1mg
- 100μg
- 500μg
- 1
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1ml
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-C100
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging100μg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-C500
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging500μg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0196-M005
- Product descriptionGeldanamycin ≥98%(HPLC)
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53200
- Product descriptionGeldanamycin
- Packaging5mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV2064
- Product descriptionGeldanamycin
- Packaging5mg
- Price$53
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV2064
- Product descriptionGeldanamycin
- Packaging25mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV2064
- Product descriptionGeldanamycin
- Packaging250mg
- Price$441
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ63397
- Product descriptionGeldanamycin 99+%
- Packaging25mg
- Price$200
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67124
- Product descriptionGeldanamycin, 1 mg/ml in DMSO, sterile-filtered
- Packaging1ml
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ63397
- Product descriptionGeldanamycin 99+%
- Packaging100mg
- Price$364
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ63397
- Product descriptionGeldanamycin 99+%
- Packaging250mg
- Price$468
- Updated2024-03-01
- Buy
- ManufacturerApexBio Technology
- Product numberA4060
- Product descriptionGeldanamycin
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4060
- Product descriptionGeldanamycin
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4060
- Product descriptionGeldanamycin
- Packaging10mM(in 1mL DMSO)
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4060
- Product descriptionGeldanamycin
- Packaging50mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4060
- Product descriptionGeldanamycin
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | BVT-0196-C100 | Geldanamycin ≥98%(HPLC) | 100μg | $20 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0196-C500 | Geldanamycin ≥98%(HPLC) | 500μg | $35 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0196-M005 | Geldanamycin ≥98%(HPLC) | 5mg | $110 | 2021-12-16 | Buy |
| AK Scientific | J53200 | Geldanamycin | 5mg | $39 | 2021-12-16 | Buy |
| AK Scientific | V2064 | Geldanamycin | 5mg | $53 | 2021-12-16 | Buy |
| AK Scientific | V2064 | Geldanamycin | 25mg | $114 | 2021-12-16 | Buy |
| AK Scientific | V2064 | Geldanamycin | 250mg | $441 | 2021-12-16 | Buy |
| Alfa Aesar | J63397 | Geldanamycin 99+% | 25mg | $200 | 2024-03-01 | Buy |
| Alfa Aesar | J67124 | Geldanamycin, 1 mg/ml in DMSO, sterile-filtered | 1ml | $280 | 2021-12-16 | Buy |
| Alfa Aesar | J63397 | Geldanamycin 99+% | 100mg | $364 | 2024-03-01 | Buy |
| Alfa Aesar | J63397 | Geldanamycin 99+% | 250mg | $468 | 2024-03-01 | Buy |
| ApexBio Technology | A4060 | Geldanamycin | 5mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A4060 | Geldanamycin | 10mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | A4060 | Geldanamycin | 10mM(in 1mL DMSO) | $160 | 2021-12-16 | Buy |
| ApexBio Technology | A4060 | Geldanamycin | 50mg | $410 | 2021-12-16 | Buy |
| ApexBio Technology | A4060 | Geldanamycin | 100mg | $650 | 2021-12-16 | Buy |
Properties
Melting point :255 °C
Boiling point :627.87°C (rough estimate)
Density :1.2443 (rough estimate)
refractive index :1.5800 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :8.42±0.70(Predicted)
color :yellow to orange
λmax :305nm(MeOH)(lit.)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
CAS DataBase Reference :30562-34-6(CAS DataBase Reference)
Boiling point :627.87°C (rough estimate)
Density :1.2443 (rough estimate)
refractive index :1.5800 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :8.42±0.70(Predicted)
color :yellow to orange
λmax :305nm(MeOH)(lit.)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
CAS DataBase Reference :30562-34-6(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding. It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function. Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.Related product price
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Suppliers and manufacturers
Henan Tianfu Chemical Co.,Ltd.
Hubei XinRunde Chemical Co., Ltd.
BOC Sciences
Chongqing Chemdad Co., Ltd
