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Postion:Product Catalog >API>Antibiotics>Other antibiotic Drugs>Geldanamycin
Geldanamycin
  • Geldanamycin
  • Geldanamycin
  • Geldanamycin
  • Geldanamycin
  • Geldanamycin

Geldanamycin NEW

Price $20 $10 $1
Package 1kg 100kg 1000kg
Min. Order: 1kg
Supply Ability: 30 tons
Update Time: 2024-10-25

Product Details

Product Name: Geldanamycin CAS No.: 30562-34-6
EC-No.: 999-999-2 Min. Order: 1kg
Purity: 0.99 Supply Ability: 30 tons
Release date: 2024/10/25

Geldanamycin is a 1,4-benzoquinone ansamycin antitumor antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate such as hepatotoxicity, further, Jilani et al. reported that geldanamycin induces the apoptosis of erythrocytes under physiological concentrations. These side effects have led to the development of geldanamycin analogues, in particular analogues containing a derivatisation at the 17 position:

Name

Geldanamycin

EINECS999-999-2
CAS No.30562-34-6Density1.23 g/cm3
PSA163.48000LogP3.43750
SolubilityDMSO: solubleMelting Point255 °C
FormulaC29H40N2O9Boiling Point783.9 °C at 760 mmHg
Molecular Weight560.645Flash Point427.9 °C
Transport InformationN/AAppearanceyellow to orange powder

Appearance and properties: Yellow to orange powder

Density: 1.23g /cm3

Boiling point: 783.9oC at 760 mmHg

Melting point: 255 °C

Flash point: 427.9oC

Refractive index: 1.559

Storage condition: -20oC

Article illustration

Article illustrationArticle illustration


Company Profile Introduction

Hebei Yanxi Chemical Co. LTD., mainly produce the Carbomer940/980/u21 and lead acetate and lead oxide, lead stearate, lead salt, at the same time operating organic intermediates, surfactants, Food additive,inorganic salt, plant extracts, cosmetics raw material, etc., through long-term development, hebei said bush chemical co., LTD. In hebei province has become a collection of r &d, production, sales in the integration of high-tech enterprises.

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  • Since: 2020-05-25
  • Address: Zhanggeji Village, Fengjiazhai Town, Guangzong County, Xingtai City, Hebei Province
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