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ChemicalBook >> CAS DataBase List >> Dronedarone

Dronedarone

Dronedarone price.
  • $50 - $4232.5
  • Product name: Dronedarone
  • CAS: 141626-36-0
  • MF: C31H44N2O5S
  • MW: 556.76
  • EINECS:
  • MDL Number:MFCD00910331
  • Synonyms:Dronedarone;N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide;N-(2-butyl-3-(4-(3-(dibutylaMino)propoxy)benzoyl)benzofuran-5-yl)MethanesulfonaMide;MethanesulfonaMide,N-[2-butyl-3-[4-[3-(dibutylaMino)propoxy]benzoyl]-5-benzofuranyl]-;CS-294;Dronedarone (SR-33589);N-[2-butyl-3-[[4-[3-(dibutylamino)propoxy]phenyl]-oxomethyl]-5-benzofuranyl]methanesulfonamide;DRONEDARONE BASE
19 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Chemenu
  • ChemScene
  • Chemtos
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
Package
  • 10mM(in 1mL DMSO)
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 5G
  • ManufacturerAK Scientific
  • Product numberW3084
  • Product descriptionDronedarone
  • Packaging25mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA404830
  • Product descriptionDronedarone 98+%
  • Packaging10mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA404830
  • Product descriptionDronedarone 98+%
  • Packaging25mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA404830
  • Product descriptionDronedarone 98+%
  • Packaging50mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024392
  • Product descriptionDRONEDARONE 95.00%
  • Packaging1G
  • Price$730.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024392
  • Product descriptionDRONEDARONE 95.00%
  • Packaging5G
  • Price$4232.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3374
  • Product descriptionDronedarone
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3374
  • Product descriptionDronedarone
  • Packaging1g
  • Price$357
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3374
  • Product descriptionDronedarone
  • Packaging5g
  • Price$973
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN90014
  • Product descriptionDronedarone
  • Packaging20mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611660
  • Product descriptionDronedarone
  • Packaging250mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611660
  • Product descriptionDronedarone
  • Packaging100mg
  • Price$397.8
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM158968
  • Product descriptionN-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide 98%
  • Packaging50mg
  • Price$299
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0384
  • Product descriptionDronedarone 99.81%
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0384
  • Product descriptionDronedarone 99.81%
  • Packaging50mg
  • Price$186
  • Updated2021-12-16
  • Buy
  • ManufacturerChemtos
  • Product numberD-2591
  • Product descriptionDronedaroneHydrochlorideLabeledd7
  • Packaging10mg
  • Price$2750
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific W3084 Dronedarone 25mg $111 2021-12-16 Buy
Ambeed A404830 Dronedarone 98+% 10mg $53 2021-12-16 Buy
Ambeed A404830 Dronedarone 98+% 25mg $90 2021-12-16 Buy
Ambeed A404830 Dronedarone 98+% 50mg $116 2021-12-16 Buy
American Custom Chemicals Corporation API0024392 DRONEDARONE 95.00% 1G $730.8 2021-12-16 Buy
American Custom Chemicals Corporation API0024392 DRONEDARONE 95.00% 5G $4232.5 2021-12-16 Buy
ApexBio Technology A3374 Dronedarone 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A3374 Dronedarone 1g $357 2021-12-16 Buy
ApexBio Technology A3374 Dronedarone 5g $973 2021-12-16 Buy
Arctom CFN90014 Dronedarone 20mg $218 2021-12-16 Buy
Biorbyt Ltd orb611660 Dronedarone 250mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb611660 Dronedarone 100mg $397.8 2021-12-16 Buy
Chemenu CM158968 N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide 98% 50mg $299 2021-12-16 Buy
ChemScene CS-0384 Dronedarone 99.81% 10mg $60 2021-12-16 Buy
ChemScene CS-0384 Dronedarone 99.81% 50mg $186 2021-12-16 Buy
Chemtos D-2591 DronedaroneHydrochlorideLabeledd7 10mg $2750 2021-12-16 Buy

Properties

Melting point :65.3°
Boiling point :683.9±65.0 °C(Predicted)
Density :1.143±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≥27.84 mg/mL in DMSO; insoluble in H2O; ≥49.8 mg/mL in EtOH
form :solid
pka :7.40±0.30(Predicted)
color :White to off-white
CAS DataBase Reference :141626-36-0(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AF is the most common form of sustained cardiac arrhythmia, with an increasing prevalence in the aging population. AF accounts for 34.5% of arrhythmia-related hospital admissions in the United States. The most significant consequences of AF include congestive heart failure, a 5-fold increased risk of stroke, and increased rate of mortality. Although a 90% conversion rate from AF to normal sinus rhythm (NSR) can be achieved with electrical cardioversion, up to 70% of these patients require additional therapy with antiarrhythmic drugs in order to maintain NSR.
Dronedarone, a close analog of amiodarone, is structurally modified to provide improved safety and pharmacokinetic profile. With the introduction of a sulfonamide group, dronedarone is less lipophilic, has lower tissue accumulation, and has a much shorter serum half-life (~24 h) compared with amiodarone. Additionally, dronedarone lacks the iodine moieties that are responsible for thyroid dysfunctions associated with amiodarone. Dronedarone is specifically indicated to reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent AF or AFL, with a recent episode of AF/AFL and associated cardiovascular risk factors, who are in sinus rhythm or who will be cardioverted. Similar to amiodarone, dronedarone is a potent blocker of multiple ion currents (including the rapidly activating delayed-rectifier potassium current, the slowly activating delayed-rectifier potassium current, the inward rectifier potassium current, the acetylcholine-activated potassium current, peak sodium current, and L-type calcium current) and exhibits antiadrenergic effects. Overall, dronedarone was well tolerated. The most common side effects were gastrointestinal in nature and included nausea, vomiting, and diarrhea.

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