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ChemicalBook >> CAS DataBase List >> Dasatinib

Dasatinib

Dasatinib price.
  • $9 - $4498.73
  • Product name: Dasatinib
  • CAS: 302962-49-8
  • MF: C22H26ClN7O2S
  • MW: 488.01
  • EINECS:801-607-0
  • MDL Number:MFCD11046566
  • Synonyms:N-(2-chloro-6-Methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-Methyl-4-pyriMidinyl]aMino]-1,3-thiazole-5-carboxaMide;sprycel Dasatinib;BMS-354825; SPRYCEL;25MG/100MG/1G;NCGC00181129;Dasatinib (Dasatinib Monohydrate) Tablet;Dasatinib (anhydrous);Dasatinib, 95+%
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  • Adipogen Life Sciences
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  • American Custom Chemicals Corporation
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  • 10mM(in 1mL DMSO)
  • 25g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1036-M005
  • Product descriptionDasatinib ≥95%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1036-M010
  • Product descriptionDasatinib ≥95%
  • Packaging10mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10239
  • Product descriptionDasatinib
  • Packaging25mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ40018
  • Product descriptionDasatinib
  • Packaging10mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10239
  • Product descriptionDasatinib
  • Packaging100mg
  • Price$66
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ93088
  • Product descriptionDasatinib
  • Packaging10g
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging50mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging100mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging250mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging1g
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging5g
  • Price$152
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging25g
  • Price$605
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA355193
  • Product descriptionN-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+%
  • Packaging100g
  • Price$1621
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002220
  • Product descriptionDASATINIB 95.00%
  • Packaging1MG
  • Price$166.95
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002220
  • Product descriptionDASATINIB 95.00%
  • Packaging1G
  • Price$1149.23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002220
  • Product descriptionDASATINIB 95.00%
  • Packaging5G
  • Price$3054.98
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1036-M005 Dasatinib ≥95% 5mg $70 2021-12-16 Buy
Adipogen Life Sciences SYN-1036-M010 Dasatinib ≥95% 10mg $97 2021-12-16 Buy
AK Scientific J10239 Dasatinib 25mg $39 2021-12-16 Buy
AK Scientific J40018 Dasatinib 10mg $59 2021-12-16 Buy
AK Scientific J10239 Dasatinib 100mg $66 2021-12-16 Buy
AK Scientific J93088 Dasatinib 10g $260 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 50mg $9 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 100mg $11 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 250mg $16 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 1g $39 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 5g $152 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 25g $605 2021-12-16 Buy
Ambeed A355193 N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide 98+% 100g $1621 2021-12-16 Buy
American Custom Chemicals Corporation API0002220 DASATINIB 95.00% 1MG $166.95 2021-12-16 Buy
American Custom Chemicals Corporation API0002220 DASATINIB 95.00% 1G $1149.23 2021-12-16 Buy
American Custom Chemicals Corporation API0002220 DASATINIB 95.00% 5G $3054.98 2021-12-16 Buy

Properties

Melting point :275-286°C
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 200 mg/ml).
pka :10.94±0.70(Predicted)
form :White powder.
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :ZBNZXTGUTAYRHI-UHFFFAOYSA-N
SMILES :S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(N2CCN(CCO)CC2)N=C(C)N=1
CAS DataBase Reference :302962-49-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Dasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family. It is effective at sub-nanomolar concentrations, inhibiting Src, Abl, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively. At nanomolar concentrations, dasatinib also blocks the activity of several other receptor and non-receptor tyrosine kinases, plus drug resistant mutants. Because of these activities, dasatinib has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.

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