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ChemicalBook >> CAS DataBase List >> Clofarabine

Clofarabine

Clofarabine price.
  • $7 - $1732.5
  • Product name: Clofarabine
  • CAS: 123318-82-1
  • MF: C10H11ClFN5O3
  • MW: 303.68
  • EINECS:631-422-9
  • MDL Number:MFCD00871077
  • Synonyms:2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE;5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;CLOFARABINE;CAFDA;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin ;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine ;Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE;5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
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Brand
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
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  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
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Package
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  • 5mg
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  • 25
  • 10mg
  • 20MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 10g
  • ManufacturerAK Scientific
  • Product numberJ53527
  • Product descriptionClofarabine
  • Packaging25mg
  • Price$26
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60927
  • Product description2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine 99+%
  • Packaging250mg
  • Price$156.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA195550
  • Product descriptionClofarabine 97%
  • Packaging10mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195550
  • Product descriptionClofarabine 97%
  • Packaging50mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195550
  • Product descriptionClofarabine 97%
  • Packaging100mg
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195550
  • Product descriptionClofarabine 97%
  • Packaging250mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195550
  • Product descriptionClofarabine 97%
  • Packaging1g
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002064
  • Product descriptionCLOFARABINE 95.00%
  • Packaging100MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002064
  • Product descriptionCLOFARABINE 95.00%
  • Packaging10MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1412
  • Product descriptionClofarabine
  • Packaging100mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1412
  • Product descriptionClofarabine
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1412
  • Product descriptionClofarabine
  • Packaging10mM(in 1mL DMSO)
  • Price$57
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS473239
  • Product descriptionClofarabine 97%
  • Packaging10mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS473239
  • Product descriptionClofarabine 97%
  • Packaging50mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS473239
  • Product descriptionClofarabine 97%
  • Packaging100mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS473239
  • Product descriptionClofarabine 97%
  • Packaging250mg
  • Price$114
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J53527 Clofarabine 25mg $26 2021-12-16 Buy
Alfa Aesar J60927 2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine 99+% 250mg $156.65 2024-03-01 Buy
Ambeed A195550 Clofarabine 97% 10mg $7 2021-12-16 Buy
Ambeed A195550 Clofarabine 97% 50mg $25 2021-12-16 Buy
Ambeed A195550 Clofarabine 97% 100mg $37 2021-12-16 Buy
Ambeed A195550 Clofarabine 97% 250mg $74 2021-12-16 Buy
Ambeed A195550 Clofarabine 97% 1g $218 2021-12-16 Buy
American Custom Chemicals Corporation API0002064 CLOFARABINE 95.00% 100MG $1732.5 2021-12-16 Buy
American Custom Chemicals Corporation API0002064 CLOFARABINE 95.00% 10MG $721.88 2021-12-16 Buy
ApexBio Technology A1412 Clofarabine 100mg $250 2021-12-16 Buy
ApexBio Technology A1412 Clofarabine 25mg $100 2021-12-16 Buy
ApexBio Technology A1412 Clofarabine 10mM(in 1mL DMSO) $57 2021-12-16 Buy
Arctom AS473239 Clofarabine 97% 10mg $15 2021-12-16 Buy
Arctom AS473239 Clofarabine 97% 50mg $36 2021-12-16 Buy
Arctom AS473239 Clofarabine 97% 100mg $65 2021-12-16 Buy
Arctom AS473239 Clofarabine 97% 250mg $114 2021-12-16 Buy

Properties

Melting point :228-2310C
Boiling point :550.0±60.0 °C(Predicted)
Density :1.4804 (estimate)
RTECS :UD7473000
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Powder
pka :12.56±0.70(Predicted)
color :white
λmax :263nm(EtOH)(lit.)
Merck :14,2372
InChIKey :INHHKRVRRUIAPA-KJHIFWANSA-N
CAS DataBase Reference :123318-82-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential. Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

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