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ChemicalBook >> CAS DataBase List >> C 646

C 646

C 646 price.
  • $7 - $1500
  • Product name: C 646
  • CAS: 328968-36-1
  • MF: C24H19N3O6
  • MW: 445.42
  • EINECS:
  • MDL Number:MFCD01784780
  • Synonyms:C 646;(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;(Z)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid C646;C 646 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;C646, p300/CBP Inhibitor
36 prices
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  • ACHEMBLOCK
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • Axon Medchem
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  • 1g
  • ManufacturerACHEMBLOCK
  • Product numberO32800
  • Product description(Z)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid 98%
  • Packaging5MG
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32800
  • Product description(Z)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid 98%
  • Packaging25MG
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32800
  • Product description(Z)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid 98%
  • Packaging100MG
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3508-M001
  • Product descriptionC646 ≥98%(NMR)
  • Packaging1mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2295AH
  • Product description4-[(4Z)-4-[[5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoicacid
  • Packaging10mg
  • Price$184
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2295AH
  • Product description4-[(4Z)-4-[[5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoicacid
  • Packaging1mg
  • Price$88
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging1mg
  • Price$7
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging5mg
  • Price$14
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging10mg
  • Price$21
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging50mg
  • Price$52
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging100mg
  • Price$77
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging250mg
  • Price$129
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA122218
  • Product descriptionC646 98+%
  • Packaging1g
  • Price$318
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0305948
  • Product description4-[4-[[5-(4,5-DIMETHYL-2-NITROPHENYL)-2-FURANYL]METHYLENE]-4,5-DIHYDRO-3-METHYL-5-OXO-1H-PYRAZOL-1-YL]BENZOIC ACID 95.00%
  • Packaging5MG
  • Price$501.81
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60146
  • Product descriptionC646 ≥98%
  • Packaging10mg
  • Price$188
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1781
  • Product descriptionC646 99%
  • Packaging2mg
  • Price$66
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK O32800 (Z)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid 98% 5MG $65 2021-12-16 Buy
ACHEMBLOCK O32800 (Z)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid 98% 25MG $145 2021-12-16 Buy
ACHEMBLOCK O32800 (Z)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoicacid 98% 100MG $450 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3508-M001 C646 ≥98%(NMR) 1mg $30 2021-12-16 Buy
AK Scientific 2295AH 4-[(4Z)-4-[[5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoicacid 10mg $184 2021-12-16 Buy
AK Scientific 2295AH 4-[(4Z)-4-[[5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoicacid 1mg $88 2021-12-16 Buy
Ambeed A122218 C646 98+% 1mg $7 2021-12-16 Buy
Ambeed A122218 C646 98+% 5mg $14 2021-12-16 Buy
Ambeed A122218 C646 98+% 10mg $21 2021-12-16 Buy
Ambeed A122218 C646 98+% 50mg $52 2021-12-16 Buy
Ambeed A122218 C646 98+% 100mg $77 2021-12-16 Buy
Ambeed A122218 C646 98+% 250mg $129 2021-12-16 Buy
Ambeed A122218 C646 98+% 1g $318 2021-12-16 Buy
American Custom Chemicals Corporation CHM0305948 4-[4-[[5-(4,5-DIMETHYL-2-NITROPHENYL)-2-FURANYL]METHYLENE]-4,5-DIHYDRO-3-METHYL-5-OXO-1H-PYRAZOL-1-YL]BENZOIC ACID 95.00% 5MG $501.81 2021-12-16 Buy
Arctom CFN60146 C646 ≥98% 10mg $188 2021-12-16 Buy
Axon Medchem Axon1781 C646 99% 2mg $66 2021-12-16 Buy

Properties

Melting point :224-226℃
Boiling point :662.6±65.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >25mg/mL
form :powder
pka :4.20±0.10(Predicted)
color :red to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :HEKJYZZSCQBJGB-XDHOZWIPSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 μM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro. C646 has been used to study the role of p300-mediated acetylation in such models as fear extinction memory and the regulation of immediate-early genes.

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