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ChemicalBook >> CAS DataBase List >> BIIB-021

BIIB-021

BIIB-021 price.
  • $25 - $2520
  • Product name: BIIB-021
  • CAS: 848695-25-0
  • MF: C14H15ClN6O
  • MW: 318.76
  • EINECS:812-781-2
  • MDL Number:MFCD15528939
  • Synonyms:CNF2024;9-[2-(2,2-diMethyl-propylaMino)ethyl]-8-(2-iodo-5-Methoxy-phenylsulfanyl)-9H-purin-6-ylaMine;CNF-2024EC102;9H-Purin-2-aMine, 6-chloro-9-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-;6-chloro-9-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)-9H-purin-2-aMine;BIIB-021;BIIB021/CNF2024;6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
41 prices
Selected condition：
Brand
  • Absolute Chiral
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 50mg
  • 250mg
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  • 50
  • 200mg
  • 10
  • 5MG
  • 10MG
  • 100mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 25MG
  • 500MG
  • ManufacturerAbsolute Chiral
  • Product numberD1070-00-N
  • Product description6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine 95%
  • Packaging100mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7555
  • Product description6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine
  • Packaging1g
  • Price$1593
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000692
  • Product descriptionBIIB-021 95.00%
  • Packaging5MG
  • Price$447
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000692
  • Product descriptionBIIB-021 95.00%
  • Packaging10MG
  • Price$468
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000692
  • Product descriptionBIIB-021 95.00%
  • Packaging25MG
  • Price$508
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000692
  • Product descriptionBIIB-021 95.00%
  • Packaging500MG
  • Price$1527.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4058
  • Product descriptionBIIB021
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4058
  • Product descriptionBIIB021
  • Packaging10mM(in 1mL DMSO)
  • Price$61
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4058
  • Product descriptionBIIB021
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4058
  • Product descriptionBIIB021
  • Packaging50mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4058
  • Product descriptionBIIB021
  • Packaging100mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60377
  • Product descriptionBIIB021
  • Packaging10mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1543
  • Product descriptionCNF2024-BIIB021 99%
  • Packaging5mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180844
  • Product descriptionBIIB021(CNF2024) >98%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18269
  • Product descriptionBIIB021 ≥98%
  • Packaging1mg
  • Price$25
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18269
  • Product descriptionBIIB021 ≥98%
  • Packaging5mg
  • Price$50
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Absolute Chiral D1070-00-N 6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine 95% 100mg $198 2021-12-16 Buy
AK Scientific X7555 6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine 1g $1593 2021-12-16 Buy
American Custom Chemicals Corporation INB0000692 BIIB-021 95.00% 5MG $447 2021-12-16 Buy
American Custom Chemicals Corporation INB0000692 BIIB-021 95.00% 10MG $468 2021-12-16 Buy
American Custom Chemicals Corporation INB0000692 BIIB-021 95.00% 25MG $508 2021-12-16 Buy
American Custom Chemicals Corporation INB0000692 BIIB-021 95.00% 500MG $1527.5 2021-12-16 Buy
ApexBio Technology A4058 BIIB021 5mg $55 2021-12-16 Buy
ApexBio Technology A4058 BIIB021 10mM(in 1mL DMSO) $61 2021-12-16 Buy
ApexBio Technology A4058 BIIB021 10mg $80 2021-12-16 Buy
ApexBio Technology A4058 BIIB021 50mg $210 2021-12-16 Buy
ApexBio Technology A4058 BIIB021 100mg $320 2021-12-16 Buy
Arctom CFN60377 BIIB021 10mg $188 2021-12-16 Buy
Axon Medchem Axon1543 CNF2024-BIIB021 99% 5mg $88 2021-12-16 Buy
Biorbyt Ltd orb180844 BIIB021(CNF2024) >98% 250mg $912.9 2021-12-16 Buy
Cayman Chemical 18269 BIIB021 ≥98% 1mg $25 2024-03-01 Buy
Cayman Chemical 18269 BIIB021 ≥98% 5mg $50 2024-03-01 Buy

Properties

Melting point :192-193℃
Boiling point :588.5±60.0 °C(Predicted)
Density :1.50
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :6.07±0.40(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

BIIB021 is a potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC50 = 38 nM), while up-regulating the expression of Hsp70 and Hsp27. It is cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft tumors. BIIB021 suppresses growth in various lymphoma cells but not in normal lymphocytes and induces apoptosis in a myelodysplastic syndrome cell line.

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