CLASTO-LACTACYSTIN BETA-LACTONE
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- $65 - $1215
- Product name: CLASTO-LACTACYSTIN BETA-LACTONE
- CAS: 154226-60-5
- MF: C10H15NO4
- MW: 213.23
- EINECS:
- MDL Number:MFCD01076526
- Synonyms:OMURALIDE;LACTACYSTIN, CLASTO-, BETA-LACTONE;BETA-CLASTOLACTACYSTIN;CLASTO-LACTACYSTIN BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
18 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 50ug
- 50μg
- 0.1mg
- 100ug
- 100μg
- 250ug
- 500ug
- 500μg
- 1mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0442-C100
- Product descriptionclasto-Lactacystin β-lactone ≥95%(HPLC)
- Packaging100μg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1685AH
- Product descriptionClasto-lactacystinbeta-lactone
- Packaging1mg
- Price$1215
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2578
- Product descriptionclasto-Lactacystin β-lactone
- Packaging50ug
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2578
- Product descriptionclasto-Lactacystin β-lactone
- Packaging100ug
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2578
- Product descriptionclasto-Lactacystin β-lactone
- Packaging500ug
- Price$654
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2578
- Product descriptionclasto-Lactacystin β-lactone
- Packaging1mg
- Price$1145
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20471
- Product descriptionClasto-lactacystin(omuralide)
- Packaging50ug
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20471
- Product descriptionClasto-lactacystin(omuralide)
- Packaging100ug
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20471
- Product descriptionClasto-lactacystin(omuralide)
- Packaging250ug
- Price$525
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20471
- Product descriptionClasto-lactacystin(omuralide)
- Packaging500ug
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20471
- Product descriptionClasto-lactacystin(omuralide)
- Packaging1mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number70988
- Product descriptionClasto-Lactacystin β-lactone ≥95%
- Packaging1mg
- Price$893
- Updated2022-04-27
- Buy
- ManufacturerCayman Chemical
- Product number70988
- Product descriptionClasto-Lactacystin β-lactone ≥95%
- Packaging500μg
- Price$488
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number70988
- Product descriptionClasto-Lactacystin β-lactone ≥95%
- Packaging100μg
- Price$124
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number70988
- Product descriptionClasto-Lactacystin β-lactone ≥95%
- Packaging50μg
- Price$65
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberL7035
- Product descriptionclasto-Lactacystin β-lactone
- Packaging0.1mg
- Price$434
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0442-C100 | clasto-Lactacystin β-lactone ≥95%(HPLC) | 100μg | $260 | 2021-12-16 | Buy |
| AK Scientific | 1685AH | Clasto-lactacystinbeta-lactone | 1mg | $1215 | 2021-12-16 | Buy |
| ApexBio Technology | A2578 | clasto-Lactacystin β-lactone | 50ug | $82 | 2021-12-16 | Buy |
| ApexBio Technology | A2578 | clasto-Lactacystin β-lactone | 100ug | $154 | 2021-12-16 | Buy |
| ApexBio Technology | A2578 | clasto-Lactacystin β-lactone | 500ug | $654 | 2021-12-16 | Buy |
| ApexBio Technology | A2578 | clasto-Lactacystin β-lactone | 1mg | $1145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20471 | Clasto-lactacystin(omuralide) | 50ug | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20471 | Clasto-lactacystin(omuralide) | 100ug | $275 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20471 | Clasto-lactacystin(omuralide) | 250ug | $525 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20471 | Clasto-lactacystin(omuralide) | 500ug | $800 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20471 | Clasto-lactacystin(omuralide) | 1mg | $1200 | 2021-12-16 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 1mg | $893 | 2022-04-27 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 500μg | $488 | 2024-03-01 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 100μg | $124 | 2024-03-01 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 50μg | $65 | 2024-03-01 | Buy |
| Sigma-Aldrich | L7035 | clasto-Lactacystin β-lactone | 0.1mg | $434 | 2024-03-01 | Buy |
Properties
Melting point :186-187°C
storage temp. :-20°C
solubility :DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form :White solid
color :White
storage temp. :-20°C
solubility :DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form :White solid
color :White
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Lactacystin is a microbial metabolite isolated from Streptomyces which is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines. Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome. It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.More related product prices
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