| Identification | Back Directory | [Name]
CLASTO-LACTACYSTIN BETA-LACTONE | [CAS]
154226-60-5 | [Synonyms]
OMURALIDE
BETA-CLASTOLACTACYSTIN
clasto-lactacystin β-lactone
Clasto-Lactacystin β-lactone
Clasto-lactacystin
(OMuralide)
CLASTO-LACTACYSTIN BETA-LACTONE
LACTACYSTIN, CLASTO-, BETA-LACTONE
1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)- | [Molecular Formula]
C10H15NO4 | [MDL Number]
MFCD01076526 | [MOL File]
154226-60-5.mol | [Molecular Weight]
213.23 |
| Chemical Properties | Back Directory | [Melting point ]
186-187°C | [storage temp. ]
-20°C | [solubility ]
DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine | [form ]
White solid | [color ]
White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin. | [Uses]
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor. | [Uses]
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor. | [Biological Activity]
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin | [Biochem/physiol Actions]
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits. |
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