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ChemicalBook >> CAS DataBase List >> 15(S)-Fluprostenol isopropyl ester

15(S)-Fluprostenol isopropyl ester

15(S)-Fluprostenol isopropyl ester price.
  • $85 - $1220
  • Product name: 15(S)-Fluprostenol isopropyl ester
  • CAS: 1420791-14-5
  • MF: C26H35F3O6
  • MW: 500.55
  • EINECS:
  • MDL Number:
  • Synonyms:DSDQWKRCNBYHOQ-BZQTUMIFSA-N;Travoprost Impurity 5（15-epi-Travoprost）;15S-Travoprost/15-epi-Travoprost/(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester;Travoprost 15-epi Diastereomer;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-;Travoprost Impurity 32;(Z)-isopropyl7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate;isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)-phenoxy]-1-butenyl]cyclopentyl]-5-heptenoate
5 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number1220AH
  • Product description15(S)-Fluprostenolisopropylester
  • Packaging1mg
  • Price$191
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16788
  • Product description15(S)-Fluprostenol isopropyl ester ≥98%
  • Packaging1mg
  • Price$85
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16788
  • Product description15(S)-Fluprostenol isopropyl ester ≥98%
  • Packaging5mg
  • Price$374
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16788
  • Product description15(S)-Fluprostenol isopropyl ester ≥98%
  • Packaging10mg
  • Price$661
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberT715605
  • Product description15-epiTravoprost
  • Packaging5mg
  • Price$1220
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1220AH 15(S)-Fluprostenolisopropylester 1mg $191 2021-12-16 Buy
Cayman Chemical 16788 15(S)-Fluprostenol isopropyl ester ≥98% 1mg $85 2024-03-01 Buy
Cayman Chemical 16788 15(S)-Fluprostenol isopropyl ester ≥98% 5mg $374 2024-03-01 Buy
Cayman Chemical 16788 15(S)-Fluprostenol isopropyl ester ≥98% 10mg $661 2024-03-01 Buy
TRC T715605 15-epiTravoprost 5mg $1220 2021-12-16 Buy

Properties

Boiling point :584.8±50.0 °C(Predicted)
Density :1.245±0.06 g/cm3(Predicted)
solubility :DMF: 15 mg/ml; DMSO: 12 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml
pka :13.43±0.20(Predicted)
form :Oil to Thick Oil
color :Colourless
Stability :Light Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost. Travoprost is the Alcon trade name for fluprostenol isopropyl ester, (Flu-Ipr) an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Flu-Ipr is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, fluprostenol, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Although data is currently not available for the activity of 15(S)-Flu-Ipr, inversion of the stereochemistry at the 15 position of ocular hypotensive prostaglandins generally lowers the potency approximately 100 fold.

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