10-Hydroxycamptothecin
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- $16 - $1490
- Product name: 10-Hydroxycamptothecin
- CAS: 19685-09-7
- MF: C20H16N2O5
- MW: 364.35
- EINECS:805-668-4
- MDL Number:MFCD00189425
- Synonyms:Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy ;hydroxy-camptotheci ;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
46 prices
Selected condition：
Brand
- Abosyn
- AccelPharmtech
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AstaTech
- AvaChem
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- JR MediChem
- Labseeker
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 20mg
- 50mg
- 500mg
- 10g
- 10
- 1g
- 5mg
- 25mg
- 5G
- 25g
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- ManufacturerAbosyn
- Product number61-3021
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98%
- Packaging1g
- Price$306
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberFB2418
- Product description10-HydroxyCamptothecin 99%
- Packaging5G
- Price$310
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11456
- Product description10-Hydroxycamptothecin
- Packaging25mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ11456
- Product description10-Hydroxycamptothecin
- Packaging100mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging100mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging1g
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging250mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging5g
- Price$56
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA155153
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging25g
- Price$557
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4745
- Product description(S)-10-Hydroxycamptothecin
- Packaging25mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4745
- Product description(S)-10-Hydroxycamptothecin
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4745
- Product description(S)-10-Hydroxycamptothecin
- Packaging100mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS020342
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
- Packaging100mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS020342
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
- Packaging250mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN99735
- Product description(S)-10-Hydroxycamptothecin ≥98%
- Packaging20mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS020342
- Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98%
- Packaging1g
- Price$55
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Abosyn | 61-3021 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98% | 1g | $306 | 2021-12-16 | Buy |
| AccelPharmtech | FB2418 | 10-HydroxyCamptothecin 99% | 5G | $310 | 2021-12-16 | Buy |
| AK Scientific | J11456 | 10-Hydroxycamptothecin | 25mg | $39 | 2021-12-16 | Buy |
| AK Scientific | J11456 | 10-Hydroxycamptothecin | 100mg | $98 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 100mg | $16 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 1g | $30 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 250mg | $30 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 5g | $56 | 2021-12-16 | Buy |
| Ambeed | A155153 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 25g | $557 | 2021-12-16 | Buy |
| ApexBio Technology | B4745 | (S)-10-Hydroxycamptothecin | 25mg | $40 | 2021-12-16 | Buy |
| ApexBio Technology | B4745 | (S)-10-Hydroxycamptothecin | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | B4745 | (S)-10-Hydroxycamptothecin | 100mg | $85 | 2021-12-16 | Buy |
| Arctom | AS020342 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% | 100mg | $16 | 2021-12-16 | Buy |
| Arctom | AS020342 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% | 250mg | $30 | 2021-12-16 | Buy |
| Arctom | CFN99735 | (S)-10-Hydroxycamptothecin ≥98% | 20mg | $40 | 2021-12-16 | Buy |
| Arctom | AS020342 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥98% | 1g | $55 | 2021-12-16 | Buy |
Properties
Melting point :265-270°C
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form :powder to crystal
pka :8.93±0.40(Predicted)
color :White to Yellow to Orange
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.More related product prices
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
Nanjing ChemLin Chemical Industry Co., Ltd.
Shanghai Zheyan Biotech Co., Ltd.
Biochempartner
Chengdu Biopurify Phytochemicals Ltd.
Accela ChemBio Inc.
Xi'an Kono chem co., Ltd.,
Shaanxi Pioneer Biotech Co., Ltd .
