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GSK8612

GSK8612 ??? ???

?? ??:: 2361659-62-1

???:: GSK8612

???(??):: GSK8612;GSK8612;GSK-8612;GSK 8612;Inhibitor,IKK,I kappa B kinase,GSK 8612,GSK-8612,GSK8612,inhibit,IκB kinase;4-(((5-Bromo-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)methyl)benzenesulfonamide;4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-4-pyrimidinyl]amino]methyl]-benzenesulfonamide;Benzenesulfonamide, 4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-4-pyrimidinyl]amino]methyl]-

CBNumber:: CB95489258

???:: C17H17BrF3N7O2S

??? ??:: 520.33

MOL ??:: 2361659-62-1.mol

?? ?? 45

GSK8612 ??

?? ?: 671.0±65.0 °C(Predicted)

??: 1.74±0.1 g/cm3(Predicted)

?? ??: -20°C

???: DMSO? ???(20 mg/ml)

?? ?? (pKa): 10.07±0.10(Predicted)

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???: ??? ?? 1? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

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Warning

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??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

GSK8612 C??? ??, ??, ??

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GSK 8612 is a highly selective TBK1 Inhibitor involved in regulating signaling pathways in immune responses.

GSK8612 ?? ?? ? ???

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GSK8612 ?? ??

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???	??	???	??	?? ?	??
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GSK8612 ?? ??:

Tigecycline 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one METHOPRENE ACID Imiquimod 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone GSK8612 GSK6853 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid GSK620 GSK591 GSK5959 ROR gamma-t-IN-1 GSK872 Cadmium sulfide

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