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Trimethylacetic anhydride

Trimethylacetic anhydride ??? ???
?? ??:
1538-75-6
???:
Trimethylacetic anhydride
???(??):
PIVALIC ANHYDRIDE;Bis(2,2-dimethylpropionic)anhydride;Pivalic anydride;Bis(pivalic)anhydride;Pivalic acid anhydride;2,2-Dimethylpropanoicanhydride;2,2-dimethylpropanoyl 2,2-dimethylpropanoate;Pivolic Anhydride;Dipivalic anhydride;PivalicAnhydride>
CBNumber:
CB9470666
???:
C10H18O3
??? ??:
186.25
MOL ??:
1538-75-6.mol
MSDS ??:
SDS

Trimethylacetic anhydride ??

?? ?
193 °C(lit.)
??
0.918 g/mL at 25 °C(lit.)
???
62.1Pa at 25℃
???
n20/D 1.409(lit.)
???
135 °F
?? ??
Inert atmosphere,Room Temperature
???
??????? ?? ??.
??? ??
??
??
???
??
Moisture Sensitive
BRN
386552
InChI
InChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3
InChIKey
PGZVFRAEAAXREB-UHFFFAOYSA-N
SMILES
C(C)(C)(C)C(=O)OC(=O)C(C)(C)C
LogP
2.15
CAS ??????
1538-75-6(CAS DataBase Reference)
EPA
Propanoic acid, 2,2-dimethyl-, anhydride (1538-75-6)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? C
?? ???? ?? 34
????? 26-36/37/39-45
????(UN No.) UN 2920 8/PG 2
WGK ?? 3
F ?????? 9-13-21
TSCA Yes
?? ?? 8
???? II
HS ?? 29159000
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H226 ??? ?? ? ?? ??? ?? ?? 3 ??
H314 ??? ?? ??? ?? ??? ??? ????? ?? ????? ?? 1A, B, C ?? GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
??????:
P210 ?·???·??·????? ????? - ?? ???.
P233 ??? ??? ?????. ??? ??? ? ?? ?? ??? ???? ?????.
P240 ??? ????? ?? ? ??????.
P280 ????/???/???/?????? ?????.
P303+P361+P353 ??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
2
3 0

Trimethylacetic anhydride C??? ??, ??, ??

??

Trimethylacetic anhydride is a pivalic acid derivative that is used in organic synthesis. The compound's reaction mechanism is believed to be the formation of an alkanoic acid, which reacts with a hydroxyl group to form an anhydride. Trimethyl acetic anhydride has been shown to have pharmacokinetic properties and can be used as a nonsteroidal anti-inflammatory drug. This compound has also been found to have a matrix effect on crystalline cellulose and is capable of forming nitrogen-containing carboxylic acids.

??? ??

clear colourless liquid

??

Trimethylacetic anhydride was used:

Trimethylacetic anhydride ?? ?? ? ???

???

?? ??

1-BOC-1,10-?????? ??? NT-BOC-?? 1-BOC-1,12-??????? N-(2-HYDROXYETHYL)-2,2-DIMETHYLPROPANAMIDE(WXC08449) N-(pivaloyloxy)benzamide N-Boc-4-ethyl-DL-phenylalanine

Trimethylacetic anhydride ?? ??

???( 255)?? ??
??? ?? ??? ?? ?? ? ??
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Trimethylacetic anhydride ?? ??:

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