?????????
????????? ??
???
95-98?C
?? ?
457.4±45.0 °C(Predicted)
??
1.15±0.1 g/cm3(Predicted)
?? ??
Controlled Substance, -20°C Freezer
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?????(?? ???), ???(?? ???)
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InChI
InChI=1/C20H26O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h3,5,11,15-19H,4,6-10H2,1-2H3/t15-,16+,17+,18-,19-,20-/s3
InChIKey
OGUASZAAVFYYIL-SBVYDUMINA-N
SMILES
[C@@]12([H])CC[C@H](OC(=O)C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3C=C[C@@]21[H] |&1:0,4,9,13,15,25,r|
CAS ??????
2590-41-2(CAS DataBase Reference)
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Warning
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P- ??
H361 ?? ?? ????? ??? ??? ??? ???
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?? 2
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P201, P202, P281, P308+P313, P405,P501
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P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
????????? C??? ??, ??, ??
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Dehydronandrolone acetate is a critical precursor in the synthesis of C7-functionalized steroidal drugs such as the new anti-breast cancer drug Fulvestrant, the treatment of menopause and postmenopausal syndrome drug Tibolone, as well as the highly effective protein anabolic hormone Mibolone. Nandrolone as starting material was first subjected to simultaneous acylation with acetic anhydride and acetyl chloride to form the intermediate, which was then brominated with N-bromosuccinimide (NBS) under basic conditions to eliminate one molecule of HBr to produce Dehydronandrolone acetate (73% yield)[1].
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Pale Yellow Solid
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Tibolone intermediate.
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Canada 1
China 171
Europe 3
Germany 1
Hungary 1
India 4
Japan 1
South Korea 1
United Kingdom 5
United States 14
Global 202
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