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LDN-214117

LDN-214117 ??? ???
?? ??:
1627503-67-6
???:
LDN-214117
???(??):
CS-1539;LDN-214117;LDN-214117;LDN214117;LDN-214117 USP/EP/BP;LDN-214117, 10 mM in DMSO;1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine;1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-;LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)
CBNumber:
CB92729368
???:
C25H29N3O3
??? ??:
419.52
MOL ??:
1627503-67-6.mol

LDN-214117 ??

?? ?
567.9±50.0 °C(Predicted)
??
1.134±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM)
?? ?? (pKa)
8.86±0.10(Predicted)
??? ??
??
??
Light yellow to yellow

??

??? ?? T
?? ???? ?? 25
????? 45

LDN-214117 C??? ??, ??, ??

??

LDN 214117 is a highly selective ALK2 inhibitor.

LDN-214117 ?? ?? ? ???

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LDN-214117 ?? ??

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