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MMP-13???

MMP-13???
MMP-13??? ??? ???
?? ??:
544678-85-5
???:
MMP-13???
???(??):
MMP-13???
???:
MMP-13 Inhibitor
???(??):
DB04760;MMP-13 Inhibitor;DB04760 (DB 04760);DB04760 (COMPOUND 4);DB04760, 10 mM in DMSO;MMP-13 Inhibitor inhibitor;N,N'-Bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide;4,6-Pyrimidinedicarboxamide, N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-;N4,N6-Bis(4-fluoro-3-Methylbenzyl)pyriMidine-4,6-dicarboxaMide
CBNumber:
CB92602854
???:
C22H20F2N4O2
??? ??:
410.42
MOL ??:
544678-85-5.mol
MSDS ??:
SDS

MMP-13??? ??

?? ?
684.6±55.0 °C(Predicted)
??
1.286±0.06 g/cm3(Predicted)
?? ??
Sealed in dry,Room Temperature
???
≤0.5mg/ml in ethanol;2mg/ml in DMSO;2mg/ml in dimethyl formamide
?? ?? (pKa)
11.79±0.46(Predicted)
??? ??
??? ??? ??.
??
Light yellow to yellow
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 29335990
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

MMP-13??? C??? ??, ??, ??

??

MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM. MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs. MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.

??? ??

White crystal

MMP-13??? ?? ?? ? ???

???

?? ??

MMP-13??? ?? ??

???( 41)?? ??
??? ?? ??? ?? ?? ? ??
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MMP-13??? ?? ??:

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